Frosch P J, Johansen J D, Menné T, Pirker C, Rastogi S C, Andersen K E, Bruze M, Goossens A, Lepoittevin J P, White I R
Department of Dermatology, Klinikum Dortmund gGmbH and University of Witten/Herdecke, Dortmund, Germany.
Contact Dermatitis. 2002 Nov;47(5):279-87. doi: 10.1034/j.1600-0536.2002.470204.x.
In order to find sensitizers additional to the current fragrance mix (FM) a series of fragrance materials (series II) was evaluated in 6 dermatological centres in Europe. 11 of the test materials were essential oils, the remaining 7 being either mixtures of isomers or simple chemicals of frequent usage in the perfume industry. 1606 patients were consecutively tested with series II and 8% FM. Each patient was classified regarding a history of adverse reactions to scented products: certain, probable, questionable, none. Reactions to FM occurred most frequently in 11.4% of the subjects. The 6 materials with the highest reactivity after the FM were ylang-ylang oil (YY) I (2.6%), YY II (2.5%), lemongrass oil (1.6%), narcissus absolute (1.3%), jasmine absolute (1.2%) and sandalwood oil (0.9%). 48 (3.0%) of the patients reacted only to materials of series II and not to FM. 6.0% of 1606 patients gave a history of adverse reactions to fragrances which was classified as certain. This group reacted to FM only in 22.9%, to series II and FM in 15.6% and to series II only in 5.2%. 63.5% of the patients reacting to both FM and 1 of the materials of series II had some type of positive fragrance history, which was higher in comparison to those with isolated reactions to FM (46.2% of 121) or to series II, respectively, (45.8% of 48). However, this difference was not statistically significant. In conclusion, the materials of series II identified a further subset of patients with a fragrance problem, which would have been missed by the current FM as the single screening tool for patch testing.
为了找到当前香料混合物（FM）之外的致敏原，一系列香料材料（系列II）在欧洲的6个皮肤科中心进行了评估。测试材料中有11种是香精油，其余7种是异构体混合物或香料工业中常用简单化学品。1606名患者连续接受系列II和8%FM测试。根据对香薰产品不良反应史对每位患者进行分类：确定、可能、可疑、无。对FM的反应最常发生在11.4%的受试者中。FM之后反应性最高的6种材料是依兰油（YY）I（2.6%）、YY II（2.5%）、柠檬草油（1.6%）、水仙净油（1.3%）、茉莉净油（1.2%）和檀香油（0.9%）。48名（3.0%）患者仅对系列II的材料有反应，而对FM无反应。1606名患者中有6.0%有对香料的不良反应史，被归类为确定。该组仅对FM有反应的占22.9%，对系列II和FM都有反应的占15.6%，仅对系列II有反应的占5.2%。对FM和系列II中的一种材料都有反应的患者中，63.5%有某种类型的阳性香料史，这一比例高于分别对FM（121例中的46.2%）或系列II（48例中的45.8%）有孤立反应的患者。然而，这种差异无统计学意义。总之，系列II的材料识别出了另一组有香料问题的患者，而当前的FM作为斑贴试验的单一筛查工具会遗漏这些患者。
