Department of Pharmaceutical Sciences, Laboratory of Nutrition and Functional Food Science, University of Antwerp, Universiteitsplein 1 (A104), 2610 Wilrijk, Belgium.
Department of Geriatric Medicine, Radboud Institute for Health Sciences, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
Nutrients. 2018 Mar 24;10(4):405. doi: 10.3390/nu10040405.
Increasing understanding arises regarding disadvantages of stimulant medication in children with ADHD (Attention-Deficit Hyperactivity Disorder). This review presents scientific findings supporting dietary antioxidant treatment of ADHD and describes substantial alterations in the immune system, epigenetic regulation of gene expression, and oxidative stress regulation in ADHD. As a result, chronic inflammation and oxidative stress could develop, which can lead to ADHD symptoms, for example by chronic T-cell-mediated neuroinflammation, as well as by neuronal oxidative damage and loss of normal cerebral functions. Therefore, modulation of immune system activity and oxidant-antioxidant balance using nutritional approaches might have potential in ADHD treatment. The use of natural antioxidants against oxidative conditions is an emerging field in the management of neurodegenerative diseases. Dietary polyphenols, for example, have antioxidant capacities as well as immunoregulatory effects and, therefore, appear appropriate in ADHD therapy. This review can stimulate the development and investigation of dietary antioxidant treatment in ADHD, which is highly desired.
人们越来越了解到，兴奋剂药物对患有注意力缺陷多动障碍（ADHD）的儿童存在不良影响。本篇综述介绍了支持 ADHD 采用饮食抗氧化剂治疗的科学发现，并描述了 ADHD 患者免疫系统、基因表达的表观遗传调控以及氧化应激调节的重大变化。因此，可能会出现慢性炎症和氧化应激，从而导致 ADHD 症状，例如通过慢性 T 细胞介导的神经炎症，以及神经元氧化损伤和正常大脑功能丧失。因此，通过营养方法调节免疫系统活性和氧化还原平衡可能对 ADHD 治疗具有潜在作用。使用天然抗氧化剂对抗氧化条件是治疗神经退行性疾病的一个新兴领域。例如，膳食多酚具有抗氧化能力和免疫调节作用，因此在 ADHD 治疗中似乎很合适。这篇综述可以激发人们对 ADHD 中饮食抗氧化治疗的开发和研究，这是非常需要的。
