Modigh Cecilia M, Bodin S Lennart V, Lillienberg Linnéa, Dahlman-Höglund Anna, Akesson Bengt, Axelsson Gösta
Department of Environmental Medicine, Göteborg University, Göteborg, Sweden.
Scand J Work Environ Health. 2002 Dec;28(6):418-28. doi: 10.5271/sjweh.694.
This study assessed paternal occupational exposure to di(2-ethylhexyl)phthalate (DEHP) in association with reduced fertility.
Men working in three plants with DEHP exposure were studied retrospectively. Male and female employees and their partners were invited to participate if they had reported a pregnancy or an attempt to achieve a pregnancy. Postal questionnaires and telephone interviews were used to collect additional data from the men and women, respectively. Information on time to pregnancy was eligible for 326 pregnancies fathered by 193 men. Male exposure to DEHP during every month of their time to pregnancy was classified into one of three exposure categories. The exposure ranged from <0.1 to 2.1 mg/m3. The fathers of only four pregnancies had DEHP exposure of >0.5 mg/m3 during the time to pregnancy. The pregnancies of employed women with unexposed partners or pregnancies of employed men unexposed during the time to pregnancy formed the reference group.
The fecundability ratio for time to pregnancy was 1.07 [95% confidence interval (95% CI) 0.84-1.35] for those with low exposure and 0.97 (95% CI 0.70-1.33) for the highly exposed after adjustment for the father's age, mother's age, and length of recall. When the analyses were restricted to first pregnancy, the fecundability ratio was 1.13 (95% Cl 0.83-1.56) for low exposure and 1.02 (95% CI 0.66-1.59) for high exposure.
Time to pregnancy is not prolonged among couples with paternal exposure to DEHP at a mean exposure level of <0.5 mg/m3.
本研究评估父亲职业性接触邻苯二甲酸二（2-乙基己基）酯（DEHP）与生育力降低之间的关系。
对在三家有DEHP接触的工厂工作的男性进行回顾性研究。如果男性和女性员工及其伴侣报告有怀孕或尝试怀孕的情况，就邀请他们参与。分别通过邮寄问卷和电话访谈从男性和女性那里收集额外数据。有193名男性生育的326次怀孕的怀孕时间信息符合要求。男性在怀孕各月期间接触DEHP的情况被分为三个接触类别之一。接触范围为<0.1至2.1毫克/立方米。只有四次怀孕的父亲在怀孕期间DEHP接触量>0.5毫克/立方米。伴侣未接触DEHP的职业女性的怀孕情况或怀孕期间未接触DEHP的职业男性的怀孕情况构成参照组。
在对父亲年龄、母亲年龄和回忆时长进行调整后，低接触组怀孕时间的受孕几率比为1.07[95%置信区间（95%CI）0.84 - 1.35]，高接触组为0.97（95%CI 0.70 - 1.33）。当分析仅限于首次怀孕时，低接触组的受孕几率比为1.13（95%CI 0.83 - 1.56），高接触组为1.02（95%CI 0.66 - 1.59）。
父亲平均接触水平<0.5毫克/立方米的夫妇，其怀孕时间并未延长。
