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抗血清素能药物未能改变大鼠中左洛啡烷诱导的刻板行为。

Failure of antiserotonergic agents to modify levallorphan-induced stereotypy in rats.

作者信息

Phillips K C, Wray S R

出版信息

Psychopharmacologia. 1975;41(3):263-5. doi: 10.1007/BF00428934.

DOI:10.1007/BF00428934
PMID:125429
Abstract

The possibilty that the stereotypic behaviour induced by levallorphan, a narcotic antagonist, might be influenced by a serotonergic system was examined. Two antiserotonergic agents, methysergide and parachlorophenylalanine, failed to modify such stereotypy implying that serotonin is not involved. It is suggested that dopamine might be the principle mediator of this behaviour.

摘要

研究了麻醉拮抗剂左洛啡烷诱导的刻板行为可能受血清素能系统影响的可能性。两种抗血清素能药物,麦角酰二乙胺和对氯苯丙氨酸,未能改变这种刻板行为,这意味着血清素不参与其中。有人提出多巴胺可能是这种行为的主要介导物。

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引用本文的文献

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本文引用的文献

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Biochemical observations on LSD-25 and Deseril.关于麦角酸二乙酰胺(LSD-25)和地西律的生化观察。
Experientia. 1962 Jun 15;18:256-7. doi: 10.1007/BF02148217.
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Tryptophan hydroxylase inhibition: the mechanism by which p-chlorophenylalanine depletes rat brain serotonin.色氨酸羟化酶抑制作用:对氯苯丙氨酸耗尽大鼠脑内5-羟色胺的机制。
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Cholinergic mechanism in brain inhibiting amphetamine-induced stereotyped behaviour.大脑中抑制苯丙胺诱导的刻板行为的胆碱能机制。
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Neuroleptic action of quaternary chlorpromazine and related drugs injected into various brain areas in rats.将季铵氯丙嗪及相关药物注射到大鼠不同脑区的抗精神病作用。
Psychopharmacologia. 1968;12(5):428-32. doi: 10.1007/BF00401348.
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Behavioural effects of some morphine antagonists and hallucinogens in the rat.某些吗啡拮抗剂和致幻剂对大鼠的行为影响。
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The effects of p-chlorophenylalanine, a serotonin depletor, on avoidance acquisition, pain sensitivity and related behavior in the rat.对氯苯丙氨酸(一种血清素消耗剂)对大鼠回避学习、痛觉敏感性及相关行为的影响。
Psychopharmacologia. 1967;10(3):204-19. doi: 10.1007/BF00401382.
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Acute effects of alpha-methyltyrosine on brain catecholamine levels and on spontaneous and amphetamine-stimulated motor activity in mice.α-甲基酪氨酸对小鼠脑儿茶酚胺水平以及自发和苯丙胺刺激的运动活动的急性影响。
Arch Int Pharmacodyn Ther. 1969 Mar;178(1):166-76.
8
The effect of p-chlorophenylalanine on behavior in rats: relation to brain serotonin and 5-hydroxyindoleacetic acid.对氯苯丙氨酸对大鼠行为的影响:与脑血清素和5-羟基吲哚乙酸的关系。
Brain Res. 1969 Oct;15(2):524-8. doi: 10.1016/0006-8993(69)90175-9.
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p-Chlorophenylalanine: a specific depletor of brain serotonin.对氯苯丙氨酸:一种脑血清素的特异性耗竭剂。
J Pharmacol Exp Ther. 1966 Dec;154(3):499-516.
10
Apomorphine-induced aggression in the rat.阿扑吗啡诱导的大鼠攻击行为。
Brain Res. 1971 Nov;34(2):323-30. doi: 10.1016/0006-8993(71)90284-8.