抗血清素能药物未能改变大鼠中左洛啡烷诱导的刻板行为。
Failure of antiserotonergic agents to modify levallorphan-induced stereotypy in rats.
作者信息
Phillips K C, Wray S R
出版信息
Psychopharmacologia. 1975;41(3):263-5. doi: 10.1007/BF00428934.
PMID:125429
Abstract
The possibilty that the stereotypic behaviour induced by levallorphan, a narcotic antagonist, might be influenced by a serotonergic system was examined. Two antiserotonergic agents, methysergide and parachlorophenylalanine, failed to modify such stereotypy implying that serotonin is not involved. It is suggested that dopamine might be the principle mediator of this behaviour.
摘要
研究了麻醉拮抗剂左洛啡烷诱导的刻板行为可能受血清素能系统影响的可能性。两种抗血清素能药物，麦角酰二乙胺和对氯苯丙氨酸，未能改变这种刻板行为，这意味着血清素不参与其中。有人提出多巴胺可能是这种行为的主要介导物。
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