Griffith D P, Bragin S, Musher D M
Invest Urol. 1976 Mar;13(5):351-3.
Previous studies from our laboratory have shown that struvite crystals form primarily as a result of urease-induced alkalinity and supersaturation. In vitro perfusion of struvite crystals with undersaturated urine caused crystal dissolution. The investigations reported herein demonstrate complete dissolution of human struvite urinary stones during 6 weeks of perfusion in vitro with undersaturated human urine. Human hydroxyapatite stones perfused similarly underwent only slight dissolution. A glycoprotein precipitated as the stones dissolved; the pathogenic significance of the glycoprotein is unknown.
我们实验室之前的研究表明，鸟粪石晶体主要是由脲酶诱导的碱化和过饱和作用形成的。用未饱和尿液对鸟粪石晶体进行体外灌注会导致晶体溶解。本文报道的研究表明，在用未饱和人尿进行6周的体外灌注过程中，人鸟粪石尿路结石完全溶解。同样进行灌注的人羟基磷灰石结石仅发生轻微溶解。结石溶解时会沉淀出一种糖蛋白；该糖蛋白的致病意义尚不清楚。
