Spaeth George L, Henderer Jeffrey, Liu Connie, Kesen Muge, Altangerel Undraa, Bayer Atilla, Katz L Jay, Myers Jonathan, Rhee Douglas, Steinmann William
William and Anna Goldberg Glaucoma Research Laboratories, Wills Eye Hospital, Jefferson Medical College, Philadelphia, Pennsylvania, USA.
Trans Am Ophthalmol Soc. 2002;100:181-5; discussion 185-6.
The major objective of this study was to test the reproducibility of a new method of estimating the amount of optic disc damage in patients with glaucoma.
The Disc Damage Likelihood Scale (DDLS) is based on the appearance of the neuroretinal rim of the optic disc corrected for disc diameter. The eight stages, extending from no damage to far advanced damage, are based on the width of the neuroretinal rim or the circumferential extent of absence of neuroretinal rim. Reproducibility was measured by two masked observers staging 48 optic nerve stereoscopic photographs by two different methods, the cup/disc ratio (c/d) and the DDLS. Also, reproducibility was assessed by three observers examining 34 eyes of 24 patients.
With regard to the photographs, the intraobserver and interobserver reproducibility was better using the DDLS than the c/d ratio (98% versus 85% for intraobserver of reproducibility, and 85% versus 74% for interobserver reproducibility). The DDLS correlated better with the Humphrey Visual Field than did any Heidelberg Retina Tomograph parameter.
In a clinical setting, the DDLS is as reproducible as, or more reproducible than, the c/d ratio system of estimating the amount of disc damage in patients with glaucoma.
本研究的主要目的是测试一种估算青光眼患者视盘损伤程度的新方法的可重复性。
视盘损伤可能性量表(DDLS)基于对视盘神经视网膜边缘外观进行视盘直径校正后得出。从无损伤到晚期损伤的八个阶段,是根据神经视网膜边缘的宽度或神经视网膜边缘缺失的圆周范围划分的。可重复性通过两名盲法观察者采用两种不同方法对48张视神经立体照片进行分期来测量,这两种方法分别是杯盘比(c/d)和DDLS。此外,由三名观察者对24例患者的34只眼睛进行检查来评估可重复性。
对于照片,使用DDLS时观察者内和观察者间的可重复性优于杯盘比(观察者内可重复性分别为98%对85%,观察者间可重复性分别为85%对74%)。DDLS与Humphrey视野的相关性比任何海德堡视网膜断层扫描参数都更好。
在临床环境中,DDLS在估算青光眼患者视盘损伤程度方面,与杯盘比系统具有相同的可重复性,或者比杯盘比系统具有更高的可重复性。