膳食脂肪摄入量作为糖尿病发病的危险因素：地中海糖尿病研究组（MGSD）的多国多中心研究
Dietary fat intake as risk factor for the development of diabetes: multinational, multicenter study of the Mediterranean Group for the Study of Diabetes (MGSD).
作者信息
Thanopoulou Anastasia C, Karamanos Basil G, Angelico Francesco V, Assaad-Khalil Samir H, Barbato Alfredo F, Del Ben Maria P, Djordjevic Predrag B, Dimitrijevic-Sreckovic Vesna S, Gallotti Cristina A, Katsilambros Nikolaos L, Migdalis Ilias N, Mrabet Mansouria M, Petkova Malina K, Roussi Demetra P, Tenconi Maria-Teresa P
机构信息
Diabetes Center, 2nd Medical Department, Athens University Medical School, Hippokration Hospital, Greece.
出版信息
Diabetes Care. 2003 Feb;26(2):302-7. doi: 10.2337/diacare.26.2.302.
OBJECTIVE
To investigate the role of dietary factors in the development of type 2 diabetes.
RESEARCH DESIGN AND METHODS
In the context of the Multinational MGSD Nutrition Study, three groups of subjects were studied: 204 subjects with recently diagnosed diabetes (RDM), 42 subjects with undiagnosed diabetes (UDM) (American Diabetes Association criteria-fasting plasma glucose [FPG] > or =126 mg/dl), and 55 subjects with impaired fasting glucose (IFG) (FPG > or =110 and <126 mg/dl). Each group was compared with a control group of nondiabetic subjects, matched one by one for center, sex, age, and BMI. Nutritional habits were evaluated by a dietary history method, validated against the 3-day diet diary. In RDM, the questionnaire referred to the nutritional habits before the diagnosis of diabetes. Demographic data were collected, and anthropometrical and biochemical measurements were taken.
RESULTS
Compared with control subjects, RDM more frequently had a family history of diabetes (49.0 vs. 14.2%; P < 0.001), exercised less (exercise index 53.5 vs. 64.4; P < 0.01), and more frequently had sedentary professions (47.5 vs. 27.4%; P < 0.001). Carbohydrates contributed less to their energy intake (53.5 vs. 55.1%; P < 0.05), whereas total fat (30.2 +/- 0.5 vs. 27.8 +/- 0.5%; P < 0.001) and animal fat (12.2 +/- 0.3 vs. 10.8 +/- 0.3%; P < 0.01) contributed more and the plant-to-animal fat ratio was lower (1.5 +/- 0.1 vs. 1.8 +/- 0.1; P < 0.01). UDM more frequently had a family history of diabetes (38.1 vs. 19.0%; P < 0.05) and sedentary professions (58.5 vs. 34.1%; P < 0.05), carbohydrates contributed less to their energy intake (47.6 +/- 1.7 vs. 52.8 +/- 1.4%; P < 0.05), total fat (34.7 +/- 1.5 vs. 30.4 +/- 1.2%; P < 0.05) and animal fat (14.2 +/- 0.9 vs. 10.6 +/- 0.7%; P < 0.05) contributed more, and the plant-to-animal fat ratio was lower (1.6 +/- 0.2 vs. 2.3 +/- 0.4; P < 0.05). IFG differed only in the prevalence of family history of diabetes (32.7 vs. 16.4%; P < 0.05).
CONCLUSIONS
Our data support the view that increased animal fat intake is associated with the presence of diabetes.
目的
探讨饮食因素在2型糖尿病发生发展中的作用。
研究设计与方法
在多国MGSD营养研究中，对三组受试者进行了研究：204例近期诊断为糖尿病的受试者（RDM）、42例未诊断糖尿病的受试者（UDM）（根据美国糖尿病协会标准——空腹血糖[FPG]≥126mg/dl）以及55例空腹血糖受损（IFG）的受试者（FPG≥110且<126mg/dl）。每组均与非糖尿病受试者对照组进行比较，按中心、性别、年龄和BMI逐一匹配。通过饮食史方法评估营养习惯，并与3天饮食日记进行对照验证。在RDM组中，问卷涉及糖尿病诊断前的营养习惯。收集人口统计学数据，并进行人体测量和生化检测。
结果
与对照组相比，RDM组有糖尿病家族史的比例更高（49.0%对14.2%；P<0.001），运动量更少（运动指数53.5对64.4；P<0.01），从事久坐职业的比例更高（47.5%对27.4%；P<0.001）。碳水化合物在其能量摄入中的占比更低（53.5%对55.1%；P<0.05），而总脂肪（30.2±0.5%对27.8±0.5%；P<0.001）和动物脂肪（12.2±0.3%对10.8±0.3%；P<0.01）的占比更高，植物性脂肪与动物性脂肪的比例更低（1.5±0.1对1.8±0.1；P<0.01）。UDM组有糖尿病家族史的比例更高（38.1%对19.0%；P<0.05），从事久坐职业的比例更高（58.5%对34.1%；P<0.05），碳水化合物在其能量摄入中的占比更低（47.6±1.7%对52.8±1.4%；P<0.05），总脂肪（34.7±1.5%对30.4±1.2%；P<0.05）和动物脂肪（14.2±0.9%对10.6±0.7%；P<0.05）的占比更高，植物性脂肪与动物性脂肪的比例更低（1.6±0.2对2.3±0.4；P<0.05）。IFG组仅在糖尿病家族史患病率方面存在差异（32.7%对16.4%；P<0.05）。
结论
我们的数据支持这样的观点，即动物脂肪摄入量增加与糖尿病的存在有关。
Zotero 插件