Ruskoné-Fourmestraux A, Attar A, Chassard D, Coffin B, Bornet F, Bouhnik Y
Service de Gastroentérologie, Hôpital Hôtel-Dieu, Paris, France.
Eur J Clin Nutr. 2003 Jan;57(1):26-30. doi: 10.1038/sj.ejcn.1601516.
We aimed to evaluate the gastro-intestinal tolerance to an indigestible bulking sweetener containing sugar alcohol using a double-blind random cross-over study.
In order to simulate their usual pattern of consumption, 12 healthy volunteers ingested maltitol or sucrose throughout the day, either occasionally (once a week for each sugar, first period) or regularly (every day for two 9 day periods, second period). In both patterns of consumption, daily sugar doses were increased until diarrhea and/or a grade 3 (ie severe) digestive symptom occurred, at which the dose level was defined as the threshold dose (TD).
In the first period (occasional consumption), the mean TD was 92+/-6 g with maltitol and 106+/-4 g with sucrose (P=0.059). The mean intensity of digestive symptoms was 1.1 and 1.3, respectively (P=NS). Diarrhea appeared in six and one subjects respectively (P=0.035). In the second period (regular consumption), the mean TD was 93+/-9 g with maltitol and 113+/-7 g with sucrose (P=0.008). The mean intensity of digestive symptoms was 1.7 and 1.2, respectively (P=NS). However, diarrhea appeared in eight and three subjects, respectively (P=0.04). Maltitol and sucrose TDs between the two periods were not different.
Under our experimental conditions, in comparison to sucrose: (a) occasional or regular consumption of maltitol is not associated with severe digestive symptoms; (b) in both patterns of maltitol consumption, diarrhea frequency is higher, but it appeared only for very high doses of maltitol, much greater than those currently used; (c) maltitol does not lead to intestinal flora adaptation after a 9 day period of consumption.
我们旨在通过一项双盲随机交叉研究评估胃肠道对含糖醇的难消化填充甜味剂的耐受性。
为了模拟他们通常的食用模式，12名健康志愿者全天摄入麦芽糖醇或蔗糖，要么偶尔摄入（每种糖每周一次，第一阶段），要么规律摄入（连续两个9天周期每天摄入，第二阶段）。在两种食用模式下，每日糖剂量都逐渐增加，直至出现腹泻和/或3级（即严重）消化症状，此时的剂量水平被定义为阈剂量（TD）。
在第一阶段（偶尔食用），麦芽糖醇的平均阈剂量为92±6克，蔗糖为106±4克（P = 0.059）。消化症状的平均强度分别为1.1和1.3（P =无显著性差异）。腹泻分别出现在6名和1名受试者中（P = 0.035）。在第二阶段（规律食用），麦芽糖醇的平均阈剂量为93±9克，蔗糖为113±7克（P = 0.008）。消化症状的平均强度分别为1.7和1.2（P =无显著性差异）。然而，腹泻分别出现在8名和3名受试者中（P = 0.04）。两个阶段之间麦芽糖醇和蔗糖的阈剂量没有差异。
在我们的实验条件下，与蔗糖相比：（a）偶尔或规律食用麦芽糖醇与严重消化症状无关；（b）在两种麦芽糖醇食用模式下，腹泻频率更高，但仅在麦芽糖醇剂量非常高时出现，远高于目前使用的剂量；（c）食用9天后，麦芽糖醇不会导致肠道菌群适应。
