EFSA J. 2009 Dec 14;7(12):1413. doi: 10.2903/j.efsa.2009.1413. eCollection 2009 Dec.
Following a request from the European Commission (EC), the Panel on Food Additives and Nutrient Sources added to Food (ANS) was asked to deliver a scientific opinion on the safety of polyglycitol syrup when used as a food additive. Polyglycitol syrup belongs to the hydrogenated starch hydrolysate syrups composed of maltitol, sorbitol and higher molecular weight polyols. In contrast to maltitol syrup EU specifications, the polyglycitol syrup has a defined concentration of sorbitol, a lower concentration of maltitol and a defined concentration of higher molecular weight polyols. Consequently, it is not covered by specifications for maltitol syrup which is an EU authorised food additive. In humans, the main reported adverse effect specifically associated with polyglycitol syrup exposure was gastric disturbance. The Panel considers that conservative estimates of the exposure to polyglycitol syrup, for consumer-only and the general population, arising from the proposed uses and use-levels, are close to, and for children even higher than, doses associated with gastric disturbances when administered as bolus doses in human trials and as reported in recent case reports.
应欧盟委员会（EC）的要求，食品添加剂和添加到食品中的营养源专家委员会（ANS）被要求就聚葡萄糖醇糖浆用作食品添加剂时的安全性提供科学意见。聚葡萄糖醇糖浆属于由麦芽糖醇、山梨糖醇和高分子量多元醇组成的氢化淀粉水解物糖浆。与麦芽糖醇糖浆的欧盟规格相比，聚葡萄糖醇糖浆具有确定浓度的山梨糖醇、较低浓度的麦芽糖醇和确定浓度的高分子量多元醇。因此，它不在作为欧盟授权食品添加剂的麦芽糖醇糖浆规格范围内。在人类中，报告的与聚葡萄糖醇糖浆接触特别相关的主要不良反应是胃部不适。专家委员会认为，对于仅消费者和普通人群而言，根据提议的用途和使用水平对聚葡萄糖醇糖浆暴露量的保守估计接近甚至高于在人体试验中作为大剂量给药以及近期病例报告中所报道的与胃部不适相关的剂量，对于儿童来说更是如此。
