Rice Louis B, Carias Lenore, Rudin Susan, Vael Carl, Goossens Herman, Konstabel Carola, Klare Ingo, Nallapareddy Sreedhar R, Huang Wenxiang, Murray Barbara E
Research and Medical Services, Louis Stokes Cleveland Veterans Affairs Medical Center and Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
J Infect Dis. 2003 Feb 1;187(3):508-12. doi: 10.1086/367711. Epub 2003 Jan 8.
An open reading frame (hyl(Efm)) with homologies to previously described hyaluronidase genes has been identified in nonstool isolates of Enterococcus faecium. E. faecium isolates (n=577) from diverse sources were screened for the presence of hyl(Efm) and esp(Efm), a putative virulence gene associated with epidemic E. faecium strains. The presence of esp(Efm) was roughly twice that of hyl(Efm), but both were found primarily in vancomycin-resistant E. faecium isolates in nonstool cultures obtained from patients hospitalized in the United States. These data suggest that specific E. faecium strains may be enriched in determinants that make them more likely to cause clinical infections. Differences in the prevalence of these strains may help explain variations in the clinical importance of multiresistant E. faecium across different continents.
在屎肠球菌的非粪便分离株中鉴定出一个与先前描述的透明质酸酶基因具有同源性的开放阅读框（hyl(Efm)）。对来自不同来源的577株屎肠球菌分离株进行筛查，以检测hyl(Efm)和esp(Efm)（一种与流行屎肠球菌菌株相关的假定毒力基因）的存在情况。esp(Efm)的存在率约为hyl(Efm)的两倍，但二者主要在从美国住院患者获得的非粪便培养物中的耐万古霉素屎肠球菌分离株中被发现。这些数据表明，特定的屎肠球菌菌株可能富集了使其更易引发临床感染的决定因素。这些菌株流行率的差异可能有助于解释多重耐药屎肠球菌在不同大陆临床重要性的差异。
