Garrido Jesús, Lerma José L, Heras Manuel, Labrador Pedro J, García Pedro, Bondía Antonio, Corbacho Luis, Tabernero José M
Service of Nephrology, University Hospital, Salamanca, Spain.
Am J Kidney Dis. 2003 Feb;41(2):488-92. doi: 10.1053/ajkd.2003.50060.
The authors report 2 cases of patients who underwent cadaveric renal transplantation from the same donor in a multiorgan extraction procedure. Both cases showed, during the first 6 months posttransplantation, a worsening in renal graft function and signs of ischemia in the homolateral lower limb. One of the cases was preceded by pain in the sciatic region. In imaging tests, a pseudoaneurysm was detected in the iliac artery in both patients. Grafts had to be removed, and the iliac arteries were ligated with posterior isolation of Aspergillus spp from the arterial vessels but not from the renal tissue. Besides surgery, medical treatment with liposomal amphotericin B was initiated with a different outcome in each patient: patient A died, whereas patient B recovered. The absence of Aspergillus spp infection in liver and heart recipients ruled out a donor-transmitted infection. The graft placements were carried out in different operating rooms, which rules out contamination during the transplantation process. All of this leads us to conclude that the infection must have occurred during the preservation phase of the kidney.
作者报告了2例在多器官摘取过程中接受来自同一供体尸体肾移植的患者。两例患者在移植后的前6个月均出现肾移植功能恶化以及同侧下肢缺血的迹象。其中1例患者在坐骨区域出现疼痛。在影像学检查中,两名患者的髂动脉均检测到假性动脉瘤。不得不切除移植肾,并结扎髂动脉,同时从动脉血管而非肾组织中分离出曲霉菌属。除手术外,两名患者均开始使用脂质体两性霉素B进行药物治疗,但结果不同:患者A死亡,而患者B康复。肝和心脏受者未感染曲霉菌属排除了供体传播感染。移植手术在不同的手术室进行,这排除了移植过程中的污染。所有这些使我们得出结论,感染肯定发生在肾脏保存阶段。