Hart D J, Spector T D
The Twin Research and Genetic Epidemiology Unit, St Thomas' Hospital, London, UK.
Osteoarthritis Cartilage. 2003 Feb;11(2):149-50. doi: 10.1053/joca.2002.0853.
The most universally accepted methods of classification of radiographic osteoarthritis (OA) is the Kellgren & Lawrence (K&L) grading system. However, there have been many criticisms of this including the grading of a doubtful osteophyte as a grade 1. We report the natural history of a given prevalent grade 1 osteophyte in a 10-year follow-up knee study. 62% of women graded at baseline with a doubtful osteophyte went on to develop true osteophytic knee OA compared with only 22% of controls with no sign of disease. So called 'doubtful' osteophytes appear to be 'real' and significantly related to OA knee and therefore cannot be ignored or classified as normal.
放射学骨关节炎（OA）最被广泛接受的分类方法是凯尔格伦和劳伦斯（K&L）分级系统。然而，对此有许多批评意见，包括将可疑骨赘评为1级。我们在一项为期10年的膝关节随访研究中报告了特定的普遍存在的1级骨赘的自然史。基线时被评为可疑骨赘的女性中，62%继续发展为真正的骨赘性膝骨关节炎，而无疾病迹象的对照组中只有22%。所谓的“可疑”骨赘似乎是“真实的”，并且与膝骨关节炎显著相关，因此不能被忽视或归类为正常。
