Chang K, Chiou W L
J Pharm Sci. 1976 Jan;65(1):53-5. doi: 10.1002/jps.2600650109.
The solubility of trichloromonofluoromethane in dog blood and tissue homogenates was measured indirectly using the head-space method at 37 degrees. These values, except that in dog blood, were used to estimate the solubility in the whole tissues or organs. In most cases, the solubility so obtained was independent of equilibrium concentration. However, a considerable concentration dependence for the solubility was observed in dog heart and kidney. The highest solubility found was in dog fat versus air, i.e., 45.6, which is almost 220 times higher than the solubility in water or normal saline. Fat solubilization and specific binding interactions appeared to be the two major factors in determining the solubility. The pharmacokinetic implications of such findings are discussed.
在37摄氏度下，采用顶空法间接测定了三氯一氟甲烷在犬血液和组织匀浆中的溶解度。除犬血液中的溶解度外，这些数值用于估算其在整个组织或器官中的溶解度。在大多数情况下，如此获得的溶解度与平衡浓度无关。然而，在犬心脏和肾脏中观察到溶解度对浓度有相当大的依赖性。所发现的最高溶解度是犬脂肪相对于空气的溶解度，即45.6，几乎比其在水或生理盐水中的溶解度高220倍。脂肪增溶作用和特异性结合相互作用似乎是决定溶解度的两个主要因素。文中讨论了这些发现的药代动力学意义。
