Fluorocarbon aerosol propellants VIII: solubility of trichloromonofluoromethane in dog blood and tissue homogenates.

The solubility of trichloromonofluoromethane in dog blood and tissue homogenates was measured indirectly using the head-space method at 37 degrees. These values, except that in dog blood, were used to estimate the solubility in the whole tissues or organs. In most cases, the solubility so obtained was independent of equilibrium concentration. However, a considerable concentration dependence for the solubility was observed in dog heart and kidney. The highest solubility found was in dog fat versus air, i.e., 45.6, which is almost 220 times higher than the solubility in water or normal saline. Fat solubilization and specific binding interactions appeared to be the two major factors in determining the solubility. The pharmacokinetic implications of such findings are discussed.