Pybus O G, Rambaut A, Holmes E C, Harvey P H
Department of Zoology, University of Oxford, South Parks Road, UK.
Syst Biol. 2002 Dec;51(6):881-8. doi: 10.1080/10635150290102582.
The relative positions of branching events in a phylogeny contain information about evolutionary and population dynamic processes. We provide new summary statistics of branching event times and describe how these statistics can be used to infer rates of species diversification from interspecies trees or rates of population growth from intraspecies trees. We also introduce a phylogenetic method for estimating the level of taxon sampling in a clade. Different evolutionary models and different sampling regimes can produce similar patterns of branching events, so it is important to consider explicitly the model assumptions involved when making evolutionary inferences. Results of an analysis of the phylogeny of the mosquito-borne flaviviruses suggest that there could be several thousand currently unidentified viruses in this clade.
系统发育中分支事件的相对位置包含有关进化和种群动态过程的信息。我们提供了分支事件时间的新汇总统计量，并描述了如何使用这些统计量从种间树推断物种多样化速率或从种内树推断种群增长速率。我们还介绍了一种用于估计一个分支中分类单元抽样水平的系统发育方法。不同的进化模型和不同的抽样方式可以产生相似的分支事件模式，因此在进行进化推断时明确考虑所涉及的模型假设非常重要。对蚊媒黄病毒系统发育的分析结果表明，这个分支中可能有数千种目前未被识别的病毒。
