Zanotto P M, Gould E A, Gao G F, Harvey P H, Holmes E C
National Environment Research Council Institute of Virology and Environmental Microbiology, Oxford, United Kingdom.
Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):548-53. doi: 10.1073/pnas.93.2.548.
The phylogeny of 123 complete envelope gene sequences was reconstructed in order to understand the evolution of tick- and mosquito-borne flaviviruses. An analysis of phylogenetic tree structure reveals a continual and asymmetric branching process in the tick-borne flaviviruses, compared with an explosive radiation in the last 200 years in viruses transmitted by mosquitoes. The distinction between these two viral groups probably reflects differences in modes of dispersal, propagation, and changes in the size of host populations. The most serious implication of this work is that growing human populations are being exposed to an expanding range of increasingly diverse viral strains.
为了了解蜱传和蚊传黄病毒的进化，重建了123个完整包膜基因序列的系统发育。对系统发育树结构的分析表明，蜱传黄病毒呈现出连续且不对称的分支过程，而蚊传病毒在过去200年中则呈现出爆发式辐射。这两种病毒组之间的差异可能反映了传播方式、繁殖方式以及宿主种群规模变化的不同。这项研究最严重的影响是，不断增长的人类人口正面临着范围不断扩大、种类日益多样的病毒株。
