Clifford G M, Smith J S, Plummer M, Muñoz N, Franceschi S
International Agency for Research on Cancer, 150, cours Albert Thomas, 69008 Lyon, France.
Br J Cancer. 2003 Jan 13;88(1):63-73. doi: 10.1038/sj.bjc.6600688.
This study investigated regional variations in the contribution made by different human papilloma (HPV) types to invasive cervical cancer (ICC). A total of 85 studies using polymerase chain reaction to estimate HPV prevalence in ICC were identified. Data on HPV prevalence were extracted separately for squamous cell carcinoma (SCC) and for adeno- and adenosquamous-carcinoma (ADC). A total of 10 058 cases (8550 SCC, 1508 ADC) were included in pooled analyses. The most common HPV types in ICC were, in order of decreasing prevalence, HPV16, 18, 45, 31, 33, 58, 52, 35, 59, 56, 6, 51, 68, 39, 82, 73, 66 and 70. In SCC, HPV16 was the predominant type (46-63%) followed by HPV18 (10-14%), 45 (2-8%), 31 (2-7%) and 33 (3-5%) in all regions except Asia, where HPV types 58 (6%) and 52 (4%) were more frequently identified. In ADC, HPV prevalence was significantly lower (76.4%) than in SCC (87.3%), and HPV18 was the predominant type in every region (37-41%), followed by 16 (26-36%) and 45 (5-7%). The overall detection of HPV DNA was similar in different regions (83-89%). A majority of ICC was associated with HPV16 or 18 in all regions, but approximately a quarter of all ICC cases were associated with one of 16 other HPV types, their distribution varying by region.
本研究调查了不同人乳头瘤病毒（HPV）类型对浸润性宫颈癌（ICC）的贡献的区域差异。共鉴定出85项使用聚合酶链反应估计ICC中HPV流行率的研究。分别提取了鳞状细胞癌（SCC）以及腺癌和腺鳞癌（ADC）的HPV流行率数据。汇总分析共纳入10058例病例（8550例SCC，1508例ADC）。ICC中最常见的HPV类型按流行率从高到低依次为HPV16、18、45、31、33、58、52、35、59、56、6、51、68、39、82、73、66和70。在SCC中，HPV16是主要类型（46 - 63%），其次是HPV18（10 - 14%）、45（2 - 8%）、31（2 - 7%）和33（3 - 5%），除亚洲外的所有地区均如此，在亚洲，HPV58（6%）和52（4%）更常被检测到。在ADC中，HPV流行率显著低于SCC（76.4%）（87.3%），HPV18在每个地区都是主要类型（37 - 41%），其次是16（26 - 36%）和45（5 - 7%）。不同地区HPV DNA的总体检测率相似（83 - 89%）。在所有地区，大多数ICC与HPV16或18相关，但所有ICC病例中约四分之一与其他16种HPV类型之一相关，其分布因地区而异。
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