Clifford G M, Smith J S, Aguado T, Franceschi S
Unit of Field and Intervention Studies, International Agency for Research on Cancer, 150, cours Albert Thomas, 69008, Lyon, France.
Br J Cancer. 2003 Jul 7;89(1):101-5. doi: 10.1038/sj.bjc.6601024.
Particular types of human papillomavirus (HPV) infection may preferentially progress from high-grade squamous intraepithelial lesions (HSIL) to squamous cell carcinoma of the cervix (SCC). We performed a meta-analysis of published data to compare HPV type distribution in HSIL and SCC. HPV16, 18 and 45 were each more prevalent in SCC than HSIL, whereas the reverse was true for other oncogenic types including HPV31, 33, 52 and 58. These data suggest that HSILs infected with HPV16, 18 and 45 preferentially progress to SCC. This may have implications for follow-up protocols of future HPV-based cervical cancer screening programmes and for HPV vaccine trials.
特定类型的人乳头瘤病毒（HPV）感染可能更易从高级别鳞状上皮内病变（HSIL）进展为宫颈鳞状细胞癌（SCC）。我们对已发表的数据进行了一项荟萃分析，以比较HSIL和SCC中HPV类型的分布情况。HPV16、18和45在SCC中的流行率均高于HSIL，而包括HPV31、33、52和58在内的其他致癌类型则相反。这些数据表明，感染HPV16、18和45的HSIL更易进展为SCC。这可能对未来基于HPV的宫颈癌筛查计划的随访方案以及HPV疫苗试验具有启示意义。
