N'-苯甲酰基-N-(叔丁基)苯甲酰肼的苯并杂环类似物的合成与杀虫活性：第3部分。N-叔丁基肼部分的修饰。

Synthesis and insecticidal activity of benzoheterocyclic analogues of N'-benzoyl-N-(tert-butyl)benzohydrazide: Part 3. Modification of N-tert-butylhydrazine moiety.

作者信息

Sawada Yoshihiro, Yanai Toshiaki, Nakagawa Harumi, Tsukamoto Yoshihisa, Tamagawa Yasushi, Yokoi Shinji, Yanagi Mikio, Toya Tetsuya, Sugizaki Hiroyasu, Kato Yasuhito, Shirakura Hidetoshi, Watanabe Tetsuo, Yajima Yoshimi, Kodama Seiichirou, Masui Akio

机构信息

Agroscience Research Laboratories, Sankyo Co Ltd, 1041, Yasu, Yasu-cho, Yasu-gun, Shiga-ken 520-2342, Japan.

出版信息

Pest Manag Sci. 2003 Jan;59(1):49-57. doi: 10.1002/ps.606.

DOI:10.1002/ps.606

PMID:12558099

Abstract

Nineteen analogues were synthesized by modifying the tert-butylhydrazine moieties of N'-tert-butyl-N'-(3,5-dimethylbenzoyl)-5-methyl-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide and N'-tert-butyl-N'-(3,5-dimethylbenzoyl)-5-methylchromane-6-carbohydrazide (chromafenozide), and the synthesized analogues were evaluated for their insecticidal activity against Spodoptera litura F. While all of the synthesized analogues had insecticidal activity inferior to those of the lead compounds, several of the analogues nonetheless showed high insecticidal activity. Chromafenozide has shown very high selectivity toward lepidopteran species.

摘要

通过修饰N'-叔丁基-N'-(3,5-二甲基苯甲酰基)-5-甲基-2,3-二氢-1,4-苯并二恶英-6-碳酰肼和N'-叔丁基-N'-(3,5-二甲基苯甲酰基)-5-甲基色满-6-碳酰肼（虫酰肼）的叔丁基肼部分，合成了19种类似物，并对合成的类似物进行了针对斜纹夜蛾的杀虫活性评估。虽然所有合成的类似物的杀虫活性均低于先导化合物，但仍有几种类似物表现出高杀虫活性。虫酰肼已显示出对鳞翅目物种具有非常高的选择性。