Gao Ying, Li Keji, Tang Shiying, Xiao Ying
Department of Nutrition and Food Hygiene, Beijing University, Beijing 100083, China.
Wei Sheng Yan Jiu. 2002 Apr;31(2):97-9.
To establish a better animal model for hyperlipidemia, three animal models with SD rats, Wistar rats and golden hamsters were explored. The semi-purified diet for rats was composed of 1% cholesterol, 10% lard, 10% yolk powder and 79% normal diet. The semi-purified diet for hamster was composed of 0.2% cholesterol, 15% lard and 85% normal diet. Serum TC, TG, HDL-C, liver cholesterol and triglyceride were assayed. Serum TG of SD rat, Wistar rat and hamster was 194.4%, 86.2% and 84.3% respectively higher than that of control after 5 weeks of experiment. Serum TC of the three groups was 76.8%, 48.3% and 134.8% respectively higher than that of control. The results suggested that hamster might be a better animal model for hypercholesterolemia and SD rat might be better for hypertriglyceridemia.
为建立更好的高脂血症动物模型，探索了以SD大鼠、Wistar大鼠和金黄仓鼠构建的三种动物模型。大鼠的半纯化饲料由1%胆固醇、10%猪油、10%蛋黄粉和79%正常饲料组成。仓鼠的半纯化饲料由0.2%胆固醇、15%猪油和85%正常饲料组成。检测血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、肝脏胆固醇和甘油三酯。实验5周后，SD大鼠、Wistar大鼠和仓鼠的血清TG分别比对照组高194.4%、86.2%和84.3%。三组的血清TC分别比对照组高76.8%、48.3%和134.8%。结果表明，仓鼠可能是更好的高胆固醇血症动物模型，而SD大鼠可能是更好的高甘油三酯血症动物模型。
