Choi Ji-Yeob, Abel Josef, Neuhaus Thomas, Ko Yon, Harth Volker, Hamajima Nobuyuki, Tajima Kazuo, Yoo Keun-Young, Park Sue Kyung, Noh Dong-Young, Han Wonshik, Choe Kuk-Jin, Ahn Sei-Hyun, Kim Sook-Un, Hirvonen Ari, Kang Daehee
Department of Preventive Medicine, General Surgery and Cancer Research Institute, Seoul National University College of Medicine, 27 Yongon-Dong, Chongno-Gu, Seoul 110-799, Korea.
Pharmacogenetics. 2003 Feb;13(2):67-72. doi: 10.1097/00008571-200302000-00002.
We examined the potential association between alcohol consumption and genetic polymorphisms in the alcohol metabolizing enzymes, CYP2E1 and ALDH2, in individual susceptibility to breast cancer in a Korean study population.
Three hundred and forty-six histologically confirmed breast cancer patients and 377 controls with no present or previous history of cancer were recruited from several teaching hospitals in Seoul during 1995-2001. The CYP2E1 RsaI polymorphism was determined by a real time PCR method, and the ALDH2 Glu487 Lys polymorphism was determined by a PCR method with confronting two-pair primers (PCR-CTPP).
The drinking women had a 1.4-fold risk for breast cancer (95% CI = 0.99-2.11) compared to never drinkers after adjustment for age and family history of breast cancer. No statistically significant overall differences were seen in the genotype frequencies between breast cancer cases and controls. However, the "ever"-drinking women with the CYP2E1 c2 allele containing genotypes had a 1.9-fold risk (95% CI = 0.99-3.83) for developing breast cancer compared to non-drinkers with the CYP2E1 c1/c1 genotype (P for interaction = 0.043).
This study therefore suggests that the CYP2E1 c2 allele may influence the individual susceptibility to breast cancer in alcohol-consuming women.
在韩国研究人群中，我们研究了酒精摄入量与酒精代谢酶CYP2E1和ALDH2的基因多态性之间的潜在关联，以及它们与个体患乳腺癌易感性的关系。
1995年至2001年期间，从首尔的几家教学医院招募了346例经组织学确诊的乳腺癌患者和377例无癌症病史的对照者。采用实时PCR方法检测CYP2E1 RsaI基因多态性，采用两对引物对抗PCR法（PCR-CTPP）检测ALDH2 Glu487 Lys基因多态性。
在调整年龄和乳腺癌家族史后，饮酒女性患乳腺癌的风险是从不饮酒者的1.4倍（95%可信区间=0.99-2.11）。乳腺癌病例组和对照组的基因型频率在总体上没有统计学显著差异。然而，与携带CYP2E1 c1/c1基因型的非饮酒者相比，携带CYP2E1 c2等位基因的“曾经”饮酒女性患乳腺癌的风险为1.9倍（95%可信区间=0.99-3.83）（交互作用P值=0.043）。
因此，本研究表明CYP2E1 c2等位基因可能影响饮酒女性个体患乳腺癌的易感性。
