Ebina Health Service Center, Kawaraguchi 1519, Ebina, Kanagawa, 243-0433, Japan.
Breast Cancer. 2019 Jul;26(4):478-484. doi: 10.1007/s12282-019-00946-7. Epub 2019 Jan 24.
Mammographic density (MD), the proportion of radiological dense breast, has been reported to be a strong risk factor for breast cancer in many studies. Epidemiological evidence indicates that alcohol consumption increases the risk of breast cancer. In Western countries, a positive association between alcohol consumption and MD has been reported.
To investigate the effect of alcohol consumption on MD, we conducted a cross-sectional analysis of healthy women enrolled in a breast cancer screening program at the Ebina Health Service Center, Japan, in 2012, comprising 477 premenopausal women and 308 postmenopausal women. Alcohol consumption was assessed using a self-report questionnaire. Unconditional logistic regression was applied to calculate the odds ratio (OR) and 95% confidence intervals (CI) while adjusting for confounders.
The study included 497 women with high breast density (HD group) and 288 women with low breast density (LD group). In all women, multivariate analysis revealed that the OR for HD was significantly increased among women with the highest alcohol intake (≥ 140 g/week of ethanol) compared with abstainers (OR 2.1, 95% CI 1.2-3.9 p = 0.01). The linear trend with increasing alcohol consumption was statistically significant (p = 0.009).
MD was positively associated with alcohol consumption in Japanese women.
乳腺密度（MD），即乳房的射线致密程度，在许多研究中被报道为乳腺癌的一个强烈危险因素。流行病学证据表明，饮酒会增加乳腺癌的风险。在西方国家，已经有研究报道了饮酒与 MD 之间存在正相关关系。
为了研究饮酒对 MD 的影响，我们对 2012 年在日本海老名健康服务中心参加乳腺癌筛查计划的健康女性进行了一项横断面分析，共纳入 477 名绝经前女性和 308 名绝经后女性。采用自我报告问卷评估饮酒情况。在调整混杂因素后，使用无条件逻辑回归计算比值比（OR）和 95%置信区间（CI）。
该研究共纳入 497 名乳腺密度较高（HD 组）和 288 名乳腺密度较低（LD 组）的女性。在所有女性中，多变量分析显示，与不饮酒者相比，饮酒量最高（≥140g/周乙醇）的女性发生 HD 的 OR 显著增加（OR 2.1，95%CI 1.2-3.9，p=0.01）。随着饮酒量的增加，线性趋势具有统计学意义（p=0.009）。
日本女性的 MD 与饮酒量呈正相关。
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