Peterlin B Matija, Trono Didier
Department of Medicine, Rosalind Russell Medical Research Center, University of California, San Francisco, California 94143-0703, USA.
Nat Rev Immunol. 2003 Feb;3(2):97-107. doi: 10.1038/nri998.
Viruses that induce chronic infections can evade immune responses. HIV is a prototype of this class of pathogen. Not only does it mutate rapidly and make its surface components difficult to access by neutralizing antibodies, but it also creates cellular hideouts, establishes proviral latency, removes cell-surface receptors and destroys immune effectors to escape eradication. A better understanding of these strategies might lead to new approaches in the fight against AIDS.
引发慢性感染的病毒能够逃避免疫反应。人类免疫缺陷病毒（HIV）就是这类病原体的典型代表。它不仅变异迅速，使中和抗体难以触及其表面成分，还会制造细胞藏身之处，建立前病毒潜伏状态，去除细胞表面受体并破坏免疫效应器以逃避根除。对这些策略的更深入理解可能会带来抗击艾滋病的新方法。
