埃塞俄比亚西北部贡德尔大学专科医院的肝炎与艾滋病毒合并感染情况

Hepatitis and HIV Co-infection at University of Gondar Specialized Referral Hospital: Northwest Ethiopia.

作者信息

Ayelign Meseret, Aynalem Melak, Berhane Nega

机构信息

Department of Molecular Biology, Specialized Referral Hospital, University of Gondar, Gondar, Ethiopia.

Department of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia.

出版信息

Hepat Med. 2021 Nov 11;13:113-120. doi: 10.2147/HMER.S337817. eCollection 2021.

DOI:10.2147/HMER.S337817

PMID:34795539

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8593689/

Abstract

BACKGROUND

Viral infections are the most common diseases. Of them, human immunodeficiency virus (HIV), hepatitis B viruses (HBV), and hepatitis C viruses (HCV) are common. When HBV or HCV becomes co-morbid with HIV, they lead to severe forms of a disease and rapid death.

OBJECTIVE

This study aimed to determine the seroprevalence and associated factors of HBV and HCV among HIV-positive study participants.

METHODS

A cross-sectional study was conducted among 81 individuals, and a non-randomized purposive sampling technique was used. From each study participant, sociodemographic and clinical data were gathered by using a pretested questionnaire and data collection sheet, respectively. Further, a venous blood sample was collected for viral load count, and HBV and HCV determination. To keep the quality of test results, commercially prepared quality control samples were used. The data were entered to EPI-Info version 7 and analyzed by using SPSS version 20. The descriptive data were summarized in percentages, median, and IQR. Logistic regression was analyzed to determine associated factors. To say the data were statistically significant, the -values should be less than 0.05.

RESULTS

A total of 81 study participants were included. Of them, 56.8% (46/81) and 67.9% (55/81) were female and urban residents, respectively. The prevalence of hepatitis co-infection was 21% (95% CI: 17%, 23%). Further, the prevalence of HBV/HIV and HCV/HIV was 13.5% (95% CI: 10.5%, 16.5%) and 8.6% (95% CI: 5.6%, 11.6%), respectively. Wise use of highly active antiretroviral therapy (HAART) 0.01 (0.00, 0.213) was a preventive factor to hepatitis infection.

CONCLUSION AND RECOMMENDATION

The HBV and HCV co-infection among HIV-positive patients was a significant public health concern. Also, having wise use of HAART can reduce exposure to hepatitis co-infection. Therefore, clear strategies on hepatitis screening and wise use of HAART to HIV would be critical.

摘要

背景

病毒感染是最常见的疾病。其中，人类免疫缺陷病毒（HIV）、乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）较为常见。当HBV或HCV与HIV合并感染时，会导致严重疾病并迅速死亡。

目的

本研究旨在确定HIV阳性研究参与者中HBV和HCV的血清流行率及相关因素。

方法

对81名个体进行了横断面研究，并采用非随机目的抽样技术。分别使用预先测试的问卷和数据收集表收集每位研究参与者的社会人口学和临床数据。此外，采集静脉血样进行病毒载量计数以及HBV和HCV检测。为保证检测结果质量，使用了商业制备的质量控制样本。数据录入EPI-Info 7版本，并使用SPSS 20版本进行分析。描述性数据以百分比、中位数和四分位间距进行汇总。采用逻辑回归分析确定相关因素。若数据具有统计学意义，则P值应小于0.05。

结果

共纳入81名研究参与者。其中，女性和城市居民分别占56.8%（46/81）和67.9%（55/81）。肝炎合并感染率为21%（95%置信区间：17%，23%）。此外，HBV/HIV和HCV/HIV的感染率分别为13.5%（95%置信区间：10.5%，16.5%）和8.6%（95%置信区间：5.6%，11.6%）。合理使用高效抗逆转录病毒疗法（HAART）0.01（0.00，0.213）是预防肝炎感染的一个因素。