NOD2/CARD15 gene mutation is not associated with susceptibility to Wegener's granulomatosis.
作者信息
Newman Bill, Rubin Laurence A, Siminovitch Katherine A
机构信息
Department of Medicine, University of Toronto and the Toronto General Hospital Research Institute, Ontario, Canada.
出版信息
J Rheumatol. 2003 Feb;30(2):305-7.
OBJECTIVE
Polymorphisms and mutations in the NOD2/CARD15 gene have been reported to increase susceptibility to Crohn's disease (CD) and the rare Blau syndrome, respectively. Both conditions are characterized by granuloma formation. We assessed the influence of variants in the CARD15 gene in another disorder characterized by granuloma, Wegener's granulomatosis (WG).
METHODS
Direct DNA sequencing of the CARD15 gene was performed on 25 patients with WG, and an additional 73 patients were genotyped for the 3 CD associated variants, R702W, G908R, and fs1007.
RESULTS
In the WG patients, 10 previously reported single nucleotide polymorphisms (SNP) were identified. No SNP were present in the WG patients at significantly different frequencies than the control population.
CONCLUSION
Our data provide no evidence to support an association between CARD15 and WG.
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