Zhao Shuwei, Sun Baochun, He Jin, Ye Qing, Lin Shunzhang, Sun Aihua
Department of Otolaryngology, Changzheng Hospital, Second Military Medical University, Shanghai 200005.
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2003 Mar;17(3):164-6.
To explore the CD44 expression in different laryngeal carcinoma tissues and their clinical significance.
Using immunohistochemistry methods to study 261 cases of archived paraffin-embedded laryngeal tissue.
The results turned out to be as follows: 1. A high level of CD44 expression was more frequently found in laryngeal carcinoma than in precarcinoma lesions and normal tissues. 2. CD44 expression correlated well with histological grades, the higher grade the lower the CD44 expression. 3. The third and fourth stages laryngeal carcinoma had stronger CD44 positive than those of the first and second stages. 4. CD44 expression in laryngeal carcinoma with cervical metastasis were higher than those without cervical metastasis. 5. To 3 and 5 years survival, CD44 positive cases had lower chance than CD44 negative cases.
These results implicates that the occurrence, development and prognosis of laryngeal carcinoma may be closely related to CD44 expression.
探讨CD44在不同喉癌组织中的表达及其临床意义。
采用免疫组织化学方法研究261例存档石蜡包埋喉组织。
结果如下：1. 喉癌中CD44高表达较癌前病变和正常组织更为常见。2. CD44表达与组织学分级密切相关，分级越高CD44表达越低。3. Ⅲ、Ⅳ期喉癌CD44阳性表达强于Ⅰ、Ⅱ期。4. 有颈部转移的喉癌CD44表达高于无颈部转移者。5. 在3年和5年生存率方面，CD44阳性病例低于CD44阴性病例。
这些结果提示喉癌的发生、发展及预后可能与CD44表达密切相关。
