Huntingtin in health and disease.
作者信息
Young Anne B
机构信息
Neurology Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
出版信息
J Clin Invest. 2003 Feb;111(3):299-302. doi: 10.1172/JCI17742.
Abstract
摘要
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本文引用的文献
1
Coenzyme Q10 and remacemide hydrochloride ameliorate motor deficits in a Huntington's disease transgenic mouse model.辅酶Q10和盐酸瑞玛西胺改善亨廷顿舞蹈病转基因小鼠模型的运动缺陷。
Neurosci Lett. 2001 Nov 27;315(3):149-53. doi: 10.1016/s0304-3940(01)02326-6.
2
Modeling Huntington's disease in cells, flies, and mice.在细胞、果蝇和小鼠中模拟亨廷顿舞蹈症。
Mol Neurobiol. 2001 Feb;23(1):21-51. doi: 10.1385/MN:23:1:21.
3
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila.组蛋白去乙酰化酶抑制剂可阻止果蝇中多聚谷氨酰胺依赖性神经变性。
Nature. 2001 Oct 18;413(6857):739-43. doi: 10.1038/35099568.
4
A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease.辅酶Q10与瑞玛西胺治疗亨廷顿舞蹈症的随机安慰剂对照试验。
Neurology. 2001 Aug 14;57(3):397-404. doi: 10.1212/wnl.57.3.397.
5
Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease.亨廷顿舞蹈病中亨廷顿蛋白介导的脑源性神经营养因子基因转录缺失。
Science. 2001 Jul 20;293(5529):493-8. doi: 10.1126/science.1059581. Epub 2001 Jun 14.
6
Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95.多聚谷氨酰胺扩展的亨廷顿蛋白通过突触后致密蛋白95促进N-甲基-D-天冬氨酸受体的敏化。
J Biol Chem. 2001 Jul 6;276(27):24713-8. doi: 10.1074/jbc.M103501200. Epub 2001 Apr 23.
7
Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo.野生型亨廷顿蛋白在体内可降低突变型亨廷顿蛋白的细胞毒性。
Am J Hum Genet. 2001 Feb;68(2):313-24. doi: 10.1086/318207. Epub 2000 Dec 20.
8
Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice.大脑和睾丸中Hdh的失活会导致小鼠进行性神经退行性变和不育。
Nat Genet. 2000 Nov;26(3):300-6. doi: 10.1038/81593.
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Environmental stimulation increases survival in mice transgenic for exon 1 of the Huntington's disease gene.环境刺激可提高亨廷顿舞蹈病基因第1外显子转基因小鼠的存活率。
Mov Disord. 2000 Sep;15(5):925-37. doi: 10.1002/1531-8257(200009)15:5<925::aid-mds1025>3.0.co;2-z.
10
Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease.米诺环素抑制胱天蛋白酶-1和胱天蛋白酶-3的表达，并延缓亨廷顿病转基因小鼠模型的死亡。
Nat Med. 2000 Jul;6(7):797-801. doi: 10.1038/77528.
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