Rehm J, Sempos C T, Trevisan M
Addiction Research Institute, Zurich, Switzerland.
J Cardiovasc Risk. 2003 Feb;10(1):15-20. doi: 10.1097/01.hjr.0000051961.68260.30.
The effect of average volume of alcohol on coronary heart disease (CHD) is J-shaped in established market economies. Light to moderate drinkers have less risk than abstainers, with heavy drinkers displaying the highest level of risk. This relationship between average volume of alcohol consumption and CHD is modified by different patterns of drinking. Heavy drinking occasions as well as drinking outside meals are related to increased CHD risk, independently of volume of drinking. Beverage type does not seem to have much impact, even though there are some indications that wine is more protective than other forms of alcohol. Physiological mechanisms have been identified to explain this complex relationship between alcohol and CHD. Since patterns of drinking are important in determining CHD risk, they should be included in future epidemiologic studies, together with biomarkers further to test hypotheses about pathways.
在成熟的市场经济体中，酒精平均摄入量对冠心病（CHD）的影响呈J形。轻度至中度饮酒者比不饮酒者患冠心病的风险更低，而重度饮酒者的风险最高。饮酒的不同模式会改变酒精摄入量与冠心病之间的这种关系。大量饮酒场合以及餐外饮酒与冠心病风险增加有关，与饮酒量无关。饮料类型似乎影响不大，尽管有一些迹象表明葡萄酒比其他形式的酒精更具保护作用。已经确定了生理机制来解释酒精与冠心病之间的这种复杂关系。由于饮酒模式在确定冠心病风险方面很重要，因此在未来的流行病学研究中应将其与生物标志物一起纳入，以进一步检验有关发病途径的假设。
