Department of Internal Medicine, Section on Hospital Medicine Wake Forest University School of Medicine Winston Salem NC USA.
Department of Biostatistics and Data Science Wake Forest University School of Medicine Winston-Salem NC USA.
J Am Heart Assoc. 2023 Sep 19;12(18):e030470. doi: 10.1161/JAHA.123.030470. Epub 2023 Sep 8.
Background The relationship between alcohol consumption and ectopic fat distribution, both known factors for cardiovascular disease, remains understudied. Therefore, we aimed to examine the association between alcohol consumption and ectopic adiposity in adults at risk for cardiovascular disease. Methods and Results In this cross-sectional analysis, we categorized alcohol intake among participants in MESA (Multi-Ethnic Study of Atherosclerosis) as follows (drinks/day): <1 (light drinking), 1 to 2 (moderate drinking), >2 (heavy drinking), former drinking, and lifetime abstention. Binge drinking was defined as consuming ≥5 drinks on 1 occasion in the past month. Visceral, subcutaneous, and intermuscular fat area, pericardial fat volume, and hepatic fat attenuation were measured using noncontrast computed tomography. Using multivariable linear regression, we examined the associations between categories of alcohol consumption and natural log-transformed fat in ectopic depots. We included 6756 MESA participants (62.1±10.2 years; 47.2% women), of whom 6734 and 1934 had chest computed tomography (pericardial and hepatic fat) and abdominal computed tomography (subcutaneous, intermuscular, and visceral fat), respectively. In adjusted analysis, heavy drinking, relative to lifetime abstention, was associated with a higher (relative percent difference) pericardial 15.1 [95% CI, 7.1-27.7], hepatic 3.4 [95% CI, 0.1-6.8], visceral 2.5 [95% CI, -10.4 to 17.2], and intermuscular 5.2 [95% CI, -6.6 to 18.4] fat but lower subcutaneous fat -3.5 [95% CI, -15.5 to 10.2]). The associations between alcohol consumption and ectopic adiposity exhibited a J-shaped pattern. Binge drinking, relative to light-to-moderate drinking, was also associated with higher ectopic fat. Conclusions Alcohol consumption had a J-shaped association with ectopic adiposity. Both heavy alcohol intake and binge alcohol drinking were associated with higher ectopic fat.
酒精摄入和异位脂肪分布均是心血管疾病的已知危险因素，但两者之间的关系仍研究不足。因此，我们旨在研究心血管疾病高危成年人的酒精摄入与异位肥胖之间的关系。
在这项横断面分析中，我们将 MESA（动脉粥样硬化多民族研究）参与者的饮酒量分为以下几类（杯/天）：<1（轻度饮酒）、1 至 2（中度饮酒）、>2（重度饮酒）、曾经饮酒和终生戒酒。狂饮定义为过去一个月内单次饮酒≥5 杯。使用非对比 CT 测量内脏、皮下和肌肉间脂肪面积、心包脂肪量和肝脂肪衰减。使用多变量线性回归，我们检查了酒精摄入类别与异位脂肪中自然对数转换脂肪之间的关系。我们纳入了 6756 名 MESA 参与者（62.1±10.2 岁；47.2%为女性），其中 6734 名和 1934 名参与者分别进行了胸部 CT（心包和肝脂肪）和腹部 CT（皮下、肌肉间和内脏脂肪）检查。在调整分析中，与终生戒酒相比，重度饮酒与更高的（相对百分比差异）心包脂肪增加 15.1[95%CI，7.1-27.7]、肝脂肪增加 3.4[95%CI，0.1-6.8]、内脏脂肪增加 2.5[95%CI，-10.4 至 17.2]和肌肉间脂肪增加 5.2[95%CI，-6.6 至 18.4]相关，但皮下脂肪减少 3.5[95%CI，-15.5 至 10.2]。酒精摄入与异位脂肪之间的关系呈 J 形。与轻中度饮酒相比，狂饮也与更高的异位脂肪相关。
酒精摄入与异位脂肪呈 J 形关联。大量饮酒和狂饮均与更高的异位脂肪相关。
