Wodehouse T, Kharitonov S A, Mackay I S, Barnes P J, Wilson R, Cole P J
Dept of Thoracic Medicine, Imperial College School of Medicine at National Heart & Lung Institute, Dovehouse Street, London, UK.
Eur Respir J. 2003 Jan;21(1):43-7. doi: 10.1183/09031936.03.00305503.
Primary ciliary dyskinesia (PCD) presents to general practitioners with symptoms pertinent to a variety of specialists because of the involvement of ciliated epithelium in the upper/lower respiratory tract, ears, eyes and genital tract. There is no easy, reliable screening test for PCD, and thus, the majority of patients remain undiagnosed. Nitric oxide (NO) is measurable in nasal air of normal subjects and found to be low in cystic fibrosis (CF) and very low in PCD. Recently, it was suggested to play an important role in regulating ciliary motility. The aim of this study was to evaluate whether measurements of nasal NO could be used to screen for PCD. Nasal NO was measured from the nasal cavity by a chemiluminescence analyser in subjects with PCD, healthy controls, CF, idiopathic bronchiectasis, Young's syndrome and lone sinusitis. Nasal NO was significantly lower in PCD (64.0+/-36.6) compared with normal controls (759+/-145.8), idiopathic bronchiectasis (734+/-163.7), CF (447.5+/-162.6), lone sinusitis (1487+/-734) and Young's syndrome (644+/-129.9). Nasal NO was also significantly lower in PCD than CF patients. Measurement of nasal nitric oxide may therefore be used clinically in various specialities to screen suspected patients for primary ciliary dyskinesia.
原发性纤毛运动障碍（PCD）由于上/下呼吸道、耳、眼和生殖道的纤毛上皮受累，常以与多种专科相关的症状就诊于全科医生。目前尚无简便、可靠的PCD筛查试验，因此，大多数患者仍未被诊断。正常受试者鼻腔空气中可检测到一氧化氮（NO），在囊性纤维化（CF）患者中NO水平较低，而在PCD患者中极低。最近有研究表明，NO在调节纤毛运动中起重要作用。本研究旨在评估鼻腔NO测量是否可用于PCD的筛查。通过化学发光分析仪对PCD患者、健康对照者、CF患者、特发性支气管扩张患者、杨氏综合征患者和单纯性鼻窦炎患者的鼻腔NO进行测量。与正常对照者（759±145.8）、特发性支气管扩张患者（734±163.7）、CF患者（447.5±162.6）、单纯性鼻窦炎患者（1487±734）和杨氏综合征患者（644±129.9）相比，PCD患者的鼻腔NO水平显著降低（64.0±36.6）。PCD患者的鼻腔NO水平也显著低于CF患者。因此，鼻腔一氧化氮测量可在临床各专科用于筛查疑似原发性纤毛运动障碍患者。
