van Stekelenburg L H, Kooman A, Tertoolen J F
Phys Med Biol. 1976 Jan;21(1):74-84. doi: 10.1088/0031-9155/21/1/006.
It is generally believed that after an intravenous injection of Hippuran its concentration in the plasma can be described as the sum of two exponentials. However, by collecting samples during the first minute after injection of the tracer, a third exponential term was found with a half-life of less than one minute. To explain its presence it was assumed that the plasma shares its Hippuran with two peripheral compartments, the rate of transfer from one compartment to another being proportional to the amount in the first of them. The proportionality factors have been determined for 20 adults and averaged. Substituting these averages in the differential equations for the distribution process, the only variable remaining is the renal excretion rate a (the fraction of plasma cleared per minute by the kidneys). If this procedure, which appears to be justified by the experimental results, is correct the shape of the plasma curve will be determined exclusively by a. It is shown that the (small) third compartment has a minor influence on the shape of the renogram curves.
一般认为，静脉注射马尿酸后，其在血浆中的浓度可用两个指数之和来描述。然而，通过在注射示踪剂后的第一分钟内采集样本，发现了第三个指数项，其半衰期小于一分钟。为了解释其存在，假设血浆与两个外周隔室共享马尿酸，从一个隔室转移到另一个隔室的速率与第一个隔室中的量成正比。已确定了20名成年人的比例因子并求平均值。将这些平均值代入分布过程的微分方程中，唯一剩下的变量就是肾脏排泄率a（每分钟被肾脏清除的血浆分数）。如果这个似乎由实验结果证明合理的程序是正确的，那么血浆曲线的形状将仅由a决定。结果表明，（小的）第三个隔室对肾图曲线的形状影响较小。
