Fagerström Karl Olov, Hughes John R, Callas Peter W
Fagerström Consulting AB and Smokers Information Center, Helsingborg, Sweden.
Nicotine Tob Res. 2002;4 Suppl 2:S141-5. doi: 10.1080/1462220021000032771.
This study investigated the long term use of Eclipse, a cigarette-like device that heats rather than burns tobacco, and the Nicorette oral inhaler, a nicotine replacement product, in a group of smokers not interested in quitting smoking. Subjects were recruited from a previous four-week controlled trial with the Eclipse and the inhaler (Fagerström, Hughes, Rasmussen, & Callas, 2000). Thirty eight subjects from the previous study were given the opportunity to continue to reduce their smoking for eight weeks and to choose Eclipse or the inhaler to aid reduction in cigarette smoking. If they did not like either of the two products they were allowed to smoke their own brand of cigarettes. A total of 39% percent chose to use the inhaler, 26% the Eclipse, and 34% neither. Number of cigarettes smoked per day decreased 86% with the Eclipse and 68% with the inhaler. Exhaled carbon monoxide increased 45% with Eclipse and decreased 47% with the inhaler. No differences were seen with craving for cigarettes between the products. Cigarette users showed stable values for cigarettes per day, exhaled carbon monoxide (CO) and nicotine/cotinine concentrations. These results replicate and extend our prior results; i.e. both Eclipse and inhaler clearly reduced smoking of traditional cigarettes and with no loss of effect over time. For Eclipse this was accompanied by maintenance of nicotine levels but increases in CO whereas for the inhaler this was accompanied by a reduction in CO intake.
本研究调查了Eclipse（一种加热而非燃烧烟草的类似香烟的装置）和尼古丁替代产品尼古丁口腔吸入器在一组无意戒烟的吸烟者中的长期使用情况。研究对象是从之前一项为期四周的使用Eclipse和吸入器的对照试验中招募的（法格斯特伦、休斯、拉斯穆森和卡拉斯，2000年）。前一项研究中的38名受试者有机会继续减少吸烟八周，并选择Eclipse或吸入器来帮助减少吸烟量。如果他们不喜欢这两种产品中的任何一种，他们可以继续吸自己品牌的香烟。共有39%的人选择使用吸入器，26%的人选择Eclipse，34%的人两者都不选。使用Eclipse时，每天吸烟量减少了86%，使用吸入器时减少了68%。使用Eclipse时呼出的一氧化碳增加了45%，使用吸入器时减少了47%。两种产品在对香烟的渴望方面没有差异。继续吸烟的人每天吸烟量、呼出一氧化碳（CO）以及尼古丁/可替宁浓度的值保持稳定。这些结果重复并扩展了我们之前的研究结果；即Eclipse和吸入器都明显减少了传统香烟的吸食量，且随着时间推移效果没有减弱。对于Eclipse来说，这伴随着尼古丁水平的维持但一氧化碳增加，而对于吸入器来说，这伴随着一氧化碳摄入量的减少。
