Milliken L A, Going S B, Houtkooper L B, Flint-Wagner H G, Figueroa A, Metcalfe L L, Blew R M, Sharp S C, Lohman T G
Department of Exercise Science and Physical Education, University of Massachusetts Boston, 100 Morrissey Blvd., 02125, USA.
Calcif Tissue Int. 2003 Apr;72(4):478-84. doi: 10.1007/s00223-001-1128-5. Epub 2003 Feb 10.
The purpose of this study was to determine the effects of 12 months of weight bearing and resistance exercise on bone mineral density (BMD) and bone remodeling (bone formation and bone resorption) in 2 groups of postmenopausal women either with or without hormone replacement therapy (HRT). Secondary aims were to characterize the changes in insulin-like growth factors-1 and -2 (IGF-1 and -2) and IGF binding protein 3 (IGFBP3) in response to exercise training. Women who were 3-10 years postmenopausal (aged 40-65 years) were included in the study. Women in the HRT and no HRT groups were randomized into the exercise intervention, resulting in four groups: (1) women not taking HRT, not exercising; (2) those taking HRT, not exercising; (3) those exercising, not taking HRT; and (4) women exercising, taking HRT. The number of subjects per group after 1 year was 27, 21, 25, and 17, respectively. HRT increased BMD at most sites whereas the combination of exercise and HRT produced increases in BMD greater than either treatment alone. Exercise training alone resulted in modest site-specific increases in BMD. Bone remodeling was suppressed in the groups taking HRT regardless of exercise status. The bone remodeling response to exercise training in women not taking HRT was not significantly different from those not exercising. However, the direction of change suggests an elevation in bone remodeling in response to exercise training, a phenomenon usually associated with bone loss. No training-induced differences in IGF-1, IGF-2, IGF-l:IGF-2 (IGF-1 : IGF-2), and IGFBP3 were detected.
本研究的目的是确定12个月的负重和抗阻运动对两组绝经后女性骨矿物质密度（BMD）和骨重塑（骨形成和骨吸收）的影响，这两组女性分别接受或未接受激素替代疗法（HRT）。次要目的是描述胰岛素样生长因子-1和-2（IGF-1和-2）以及IGF结合蛋白3（IGFBP3）在运动训练后的变化。研究纳入了绝经3至10年（年龄40至65岁）的女性。接受HRT和未接受HRT的女性被随机分为运动干预组，从而形成四组：（1）未接受HRT且不运动的女性；（2）接受HRT且不运动的女性；（3）运动但未接受HRT的女性；（4）运动且接受HRT的女性。1年后每组的受试者人数分别为27、21、25和17。HRT使大多数部位的BMD增加，而运动与HRT联合使用使BMD的增加幅度大于单独使用任何一种治疗方法。单独的运动训练导致BMD在特定部位有适度增加。无论运动状态如何，接受HRT的组中骨重塑均受到抑制。未接受HRT的女性对运动训练的骨重塑反应与不运动的女性无显著差异。然而，变化方向表明运动训练会使骨重塑增加，这一现象通常与骨质流失有关。未检测到训练引起的IGF-1、IGF-2、IGF-1:IGF-2（IGF-1:IGF-2）和IGFBP3的差异。
