Hesse B, Nielsen I
Scand J Clin Lab Invest. 1976 Jan;36(1):23-8. doi: 10.1080/00365517609068014.
The effect on plasma renin activity of intravenous furosemide combined with saline replacement of the volume depletion was studied in twelve patients with insignificant heart disease. In ten of the patients the investigation was repeated without saline replacement. It was found that saline infusion, reducing or eliminating hemoconcentration, had no significant influence on the marked plasma renin increase. In eight of the patients the combined furosemide-saline study was performed during right-hear catheterization. Decrease in atrial pressures, known to occur within 15 min after furosemide intravenously, was virtually absent with the saline replacement. It is concluded that plasma volume reduction after intravenous furosemide is responsible for decreased filling pressures of the ventricles but not for plasma renin increase.
在12例轻度心脏病患者中研究了静脉注射呋塞米联合生理盐水补充以纠正容量缺失对血浆肾素活性的影响。其中10例患者在不补充生理盐水的情况下重复进行了该研究。结果发现，生理盐水输注减轻或消除了血液浓缩，但对血浆肾素显著升高无明显影响。8例患者在右心导管检查期间进行了呋塞米 - 生理盐水联合研究。已知静脉注射呋塞米后15分钟内心房压力会下降，但在补充生理盐水的情况下几乎未出现这种情况。得出的结论是，静脉注射呋塞米后血浆容量减少是心室充盈压降低的原因，但不是血浆肾素升高的原因。
