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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Hesse B, Nielsen I, Lund-Jacobsen H

Clin Sci Mol Med. 1975 Dec;49(6):551-5. doi: 10.1042/cs0490551.

Nine paatients with clinically unimportant heart disease or benign essential hypertension were given frusemide intravenously during right-heart catheterization. 2. Pressures in both atria decreased rapidly and in parallel. The magnitude of the pressure decrease was clearly related to decrease in plasma volume loss. 3. Plasma renin activity increased significantly after 5 min (P less than 0-01), but did not correlate with plasma volume loss. 4. Venous tone in the forearm was unchanged. 5. It is concluded that the pressure reduction was secondary to plasma volume depletion through diuresis and that increased plasma renin activity was mainly caused by intrarenal changes.

9例患有临床意义不大的心脏病或良性原发性高血压的患者在右心导管插入术期间接受了静脉注射速尿。2. 两个心房的压力迅速且平行下降。压力下降的幅度明显与血浆容量减少有关。3. 5分钟后血浆肾素活性显著增加（P小于0.01），但与血浆容量减少无关。4. 前臂静脉张力未改变。5. 得出的结论是，压力降低是通过利尿导致血浆容量减少的继发结果，血浆肾素活性增加主要是由肾内变化引起的。

Hesse B, Nielsen I, Lund-Jacobsen H

Clin Sci Mol Med. 1975 Dec;49(6):551-5. doi: 10.1042/cs0490551.

Nine paatients with clinically unimportant heart disease or benign essential hypertension were given frusemide intravenously during right-heart catheterization. 2. Pressures in both atria decreased rapidly and in parallel. The magnitude of the pressure decrease was clearly related to decrease in plasma volume loss. 3. Plasma renin activity increased significantly after 5 min (P less than 0-01), but did not correlate with plasma volume loss. 4. Venous tone in the forearm was unchanged. 5. It is concluded that the pressure reduction was secondary to plasma volume depletion through diuresis and that increased plasma renin activity was mainly caused by intrarenal changes.

9例患有临床意义不大的心脏病或良性原发性高血压的患者在右心导管插入术期间接受了静脉注射速尿。2. 两个心房的压力迅速且平行下降。压力下降的幅度明显与血浆容量减少有关。3. 5分钟后血浆肾素活性显著增加（P小于0.01），但与血浆容量减少无关。4. 前臂静脉张力未改变。5. 得出的结论是，压力降低是通过利尿导致血浆容量减少的继发结果，血浆肾素活性增加主要是由肾内变化引起的。