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一种用于预防舌癌近距离放射治疗所致放射性骨坏死的间隔器的临床研究

Clinical study of a spacer to help prevent osteoradionecrosis resulting from brachytherapy for tongue cancer.

作者信息

Obinata Kenichi, Ohmori Keiichi, Tuchiya Kazuhiko, Nishioka Takeshi, Shirato Hiroki, Nakamura Motoyasu

机构信息

Division of Oral and Maxillofacial Disorders, Hokkaido University Dental Hospital, Sapporo, Japan.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003 Feb;95(2):246-50. doi: 10.1067/moe.2003.94.

Abstract

OBJECTIVE

We sought to describe a simple method to construct a spacer and to evaluate with the use of computed tomography the spacer's effectiveness in preventing osteoradionecrosis of the mandible.

STUDY DESIGN

Fifty-three patients with oral tongue cancers who were treated by means of interstitial brachytherapy were included in this study. Patients underwent a computed tomography examination immediately after the implantation of radioactive sources, with the spacers in place. Distances between the radioactive sources and the lingual surfaces of the mandible were measured on transverse computed tomographs and were evaluated in terms of the development of osteoradionecrosis in the mandible.

RESULTS

Statistically significant differences in the frequency of osteoradionecrosis were observed between patients who had received spacers equal to or thicker than 5 mm and those who had received spacers less than 5 mm thick.

CONCLUSION

A spacer should have a minimum thickness of 5 mm on its lingual flange to prevent the development of osteoradionecrosis of the mandible.

摘要

目的

我们试图描述一种构建间隔物的简单方法,并利用计算机断层扫描评估该间隔物在预防下颌骨放射性骨坏死方面的有效性。

研究设计

本研究纳入了53例接受组织间近距离放射治疗的口腔舌癌患者。患者在植入放射源后立即进行计算机断层扫描检查,此时间隔物已就位。在横断计算机断层扫描上测量放射源与下颌骨舌面之间的距离,并根据下颌骨放射性骨坏死的发生情况进行评估。

结果

接受厚度等于或大于5mm间隔物的患者与接受厚度小于5mm间隔物的患者在放射性骨坏死发生率上存在统计学显著差异。

结论

间隔物舌侧凸缘的最小厚度应为5mm,以防止下颌骨放射性骨坏死的发生。

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