用于苔藓抑素7全合成的通向正宗“南半球”中间体的新的简化途径。

New, abridged pathway to Masamune's "southern hemisphere" intermediate for the total synthesis of bryostatin 7.

作者信息

Hale Karl J, Frigerio Mark, Manaviazar Soraya

机构信息

The Christopher Ingold Laboratories, The Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, United Kingdom.

出版信息

Org Lett. 2003 Feb 20;5(4):503-5. doi: 10.1021/ol027393m.

DOI:10.1021/ol027393m

PMID:12583754

Abstract

[reaction: see text] The "Southern Hemisphere" intermediate 2, used by Masamune and co-workers for their asymmetric total synthesis of bryostatin 7 (1), has been synthesized from (E)-1,4-hexadiene (11) by a 24-step pathway that has a longest linear sequence of only 20 steps. This is the shortest synthesis of 2 so far recorded, and moreover, it is fully stereocontrolled.

摘要

[反应：见正文] 正木及其同事用于不对称全合成苔藓抑素7（1）的“南半球”中间体2，已通过一条24步的路线从（E）-1,4-己二烯（11）合成，该路线最长线性序列仅20步。这是迄今为止记录的2的最短合成路线，而且它是完全立体控制的。