Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA.
J Am Chem Soc. 2011 Jun 22;133(24):9228-31. doi: 10.1021/ja203034k. Epub 2011 May 27.
The total synthesis of bryostatin 9 was accomplished using a uniquely step-economical and convergent Prins-driven macrocyclization strategy. At 25 linear and 42 total steps, this is currently the most concise and convergent synthesis of a potent bryostatin.
采用独特的、具有经济效益的普林斯（Prins）驱动的大环化策略，实现了 bryostatin 9 的全合成。该路线共 25 步线性反应和 42 步总反应，是目前为止简洁度和汇聚度最高的一种合成强效 bryostatin 的方法。
