Zetner Karl, Rothmueller Gabriele
University of Veterinary Medicine, Clinic of Surgery and Ophthalmology, Veterinärplatz 1, 1210 Wien, Austria.
Vet Ther. 2002 Winter;3(4):441-52.
Following pretreatment with clindamycin, cleaning, scaling, polishing, and curettage, six beagles that were patients at the Dental Department of the Clinic for Surgery and Ophthalmology of the University of Veterinary Medicine of Vienna received a doxycycline polymer filling (Doxirobe, Pharmacia Animal Health) in periodontal pockets of teeth 204, 208, 304, and 309. Gingivitis index, gingival crevicular fluid, probing depth, and attachment loss were determined before and 6 and 12 weeks after treatment. Teeth 104, 108, 404, and 409 did not receive antibiotic therapy but were pretreated in the same manner as the doxycycline-treated teeth. Pocket depth for teeth treated with doxycycline was significantly reduced (improved) by 39% after 6 weeks (P =.001) and by 35% after 12 weeks (P =.001). Pockets around control teeth were improved after cleaning and curettage but were still significantly deeper than around teeth treated with doxycycline. Compared with control teeth, teeth treated with doxycycline had significantly less gingival crevicular fluid after treatment (P =.001). Teeth treated with doxycycline gained significant attachment after 6 (42%) and 12 (38%) weeks. Significantly fewer bacteria were harvested from doxycycline-treated teeth than from control teeth. The gingival index was significantly lower in the doxycycline-treated teeth than in the control teeth 6 (P =.002) and 12 (P =.007) weeks after treatment. Local application of doxycycline complements traditional subgingival curettage therapy in a reasonable and effective way and can significantly improve treatment success, especially with regard to pocket depth reduction and attachment gain.
在用克林霉素进行预处理、清洁、刮治、抛光和刮治后，维也纳兽医大学外科与眼科诊所牙科的六只比格犬患者在牙齿204、208、304和309的牙周袋中接受了强力霉素聚合物填充（多西环素，辉瑞动物保健公司）。在治疗前以及治疗后6周和12周测定牙龈炎指数、龈沟液、探诊深度和附着丧失。牙齿104、108、404和409未接受抗生素治疗，但预处理方式与强力霉素治疗的牙齿相同。用强力霉素治疗的牙齿的牙周袋深度在6周后显著降低（改善）了39%（P = 0.001），在12周后降低了35%（P = 0.001）。对照牙齿周围的牙周袋在清洁和刮治后有所改善，但仍明显比强力霉素治疗的牙齿周围的牙周袋深。与对照牙齿相比，用强力霉素治疗的牙齿在治疗后龈沟液明显减少（P = 0.001）。用强力霉素治疗的牙齿在6周（42%）和12周（38%）后获得了显著的附着。从强力霉素治疗的牙齿中采集到的细菌明显少于对照牙齿。治疗后6周（P = 0.002）和12周（P = 0.007），强力霉素治疗的牙齿的牙龈指数明显低于对照牙齿。局部应用强力霉素以合理有效的方式补充了传统的龈下刮治治疗，并且可以显著提高治疗成功率，特别是在减少牙周袋深度和增加附着方面。
