Jennes Marie-Elise, Naumann Michael, Peroz Simon, Beuer Florian, Schmidt Franziska
Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, Assmans-hauser Straße 4-6, 14197 Berlin, Germany.
Antibiotics (Basel). 2021 Nov 5;10(11):1350. doi: 10.3390/antibiotics10111350.
The aim of the present study was to systematically review studies investigating antibacterial implant abutment surfaces or coatings, which may suppress bacterial growth to prevent plaque-induced peri-implant inflammatory disease. Data were collected after identification of case, assay/laboratory procedure, predicate/reference standard and outcome (CAPO). Seven hundred and twenty (720) records were identified through data base searching. After screening nine publications fulfilled inclusion criteria and were included. The following surfaces/coatings showed antibacterial properties: Electrochemical surface modification of titanium by the anodic spark deposition technique; doxycycline coating by cathodic polarization; silver coating by DC plasma sputter; titanium nitride; zirconium nitride and microwave assistant nano silver coating. Since the current state of the literature is rather descriptive, a meta-analysis was not performed. While several abutment coatings showed to have antibacterial capacity, some of them also influenced the behavior of investigated human cells. None of the studies investigated the long-term effect of surface modifications. Since surface changes are the main contributing factor in the development of antibacterial effects, the biodegradation behavior must be characterized to understand its durability. To date there is no effective structure, material or strategy to avoid peri-implant inflammation used as clinical routine. Furthermore, clinical studies are scarce.
本研究的目的是系统回顾调查抗菌种植体基台表面或涂层的研究，这些表面或涂层可能抑制细菌生长，以预防菌斑诱导的种植体周围炎症性疾病。在确定病例、检测/实验室程序、对照/参考标准和结果（CAPO）后收集数据。通过数据库检索识别出720条记录。经过筛选，9篇出版物符合纳入标准并被纳入。以下表面/涂层显示出抗菌性能：阳极火花沉积技术对钛进行电化学表面改性；阴极极化法制备的强力霉素涂层；直流等离子体溅射法制备的银涂层；氮化钛；氮化锆和微波辅助纳米银涂层。由于目前的文献状态相当具有描述性，因此未进行荟萃分析。虽然几种基台涂层显示出具有抗菌能力，但其中一些也影响了所研究的人类细胞的行为。没有一项研究调查表面改性的长期效果。由于表面变化是抗菌效果产生的主要因素，因此必须表征其生物降解行为以了解其耐久性。迄今为止，尚无有效的结构、材料或策略可作为临床常规方法来避免种植体周围炎症。此外，临床研究很少。
