Devasagayam T P A, Sainis K B
Cell Biology Division, Bhabha Atomic Research Centre, Mumbai 400 085, India.
Indian J Exp Biol. 2002 Jun;40(6):639-55.
During the functioning of the immune system, such as in phagocytosis, reactive oxygen and nitrogen species are generated. If they are left unchecked they can affect the components of the immune system by inducing oxidative damage. This is more so in the elderly or during inflammation where there is excess generation of these reactive species than can be taken care of by the defenses in the form of antioxidants. Dietary supplementation with antioxidants may greatly help in such conditions. There are some indications of possible benefits of antioxidant supplementation. Natural compounds from medicinal plants having antioxidant and immunomodulatory activities have potential as therapeutic agents in this regard. Indian medicinal plants with these activities have been identified and their antioxidant and immunomodulatory effects reviewed. The possible future prospects in this regard are also outlined.
在免疫系统发挥功能的过程中，例如在吞噬作用中，会产生活性氧和活性氮物质。如果这些物质不加以控制，它们会通过诱导氧化损伤来影响免疫系统的组成部分。在老年人或炎症期间情况更是如此，此时这些活性物质的产生过多，超出了抗氧化剂形式的防御机制所能处理的范围。在这种情况下，膳食补充抗氧化剂可能会有很大帮助。有一些迹象表明补充抗氧化剂可能有益。具有抗氧化和免疫调节活性的药用植物中的天然化合物在这方面有作为治疗剂的潜力。已鉴定出具有这些活性的印度药用植物，并对其抗氧化和免疫调节作用进行了综述。还概述了这方面可能的未来前景。
