World J Gastroenterol. 2010 Jun 7;16(21):2579-88. doi: 10.3748/wjg.v16.i21.2579.
Nonalcoholic fatty liver disease (NAFLD) is a common clinical condition which is associated with metabolic syndrome in 70% of cases. Inappropriate dietary fat intake, excessive intake of soft drinks, insulin resistance and increased oxidative stress combine to increase free fatty acid delivery to the liver, and increased hepatic triglyceride accumulation contributes to fatty liver. Regular soft drinks have high fructose corn syrup which contains basic sugar building blocks, fructose 55% and glucose 45%. Soft drinks are the leading source of added sugar worldwide, and have been linked to obesity, diabetes, and metabolic syndrome. The consumption of soft drinks can increase the prevalence of NAFLD independently of metabolic syndrome. During regular soft drinks consumption, fat accumulates in the liver by the primary effect of fructose which increases lipogenesis, and in the case of diet soft drinks, by the additional contribution of aspartame sweetener and caramel colorant which are rich in advanced glycation end products that potentially increase insulin resistance and inflammation. This review emphasizes some hard facts about soft drinks, reviews fructose metabolism, and explains how fructose contributes to the development of obesity, diabetes, metabolic syndrome, and NAFLD.
非酒精性脂肪性肝病（NAFLD）是一种常见的临床病症，其在 70%的病例中与代谢综合征相关。不适当的膳食脂肪摄入、过量饮用软饮料、胰岛素抵抗和氧化应激增加，共同导致游离脂肪酸向肝脏输送增加，肝内三酰甘油积累导致脂肪肝。普通软饮料含有高果糖玉米糖浆，其中包含基本的糖构建块，果糖 55%，葡萄糖 45%。软饮料是全球添加糖的主要来源，与肥胖、糖尿病和代谢综合征有关。软饮料的摄入可独立于代谢综合征增加 NAFLD 的患病率。在常规软饮料摄入期间，果糖通过增加脂肪生成的主要作用导致脂肪在肝脏中积累，而在节食软饮料的情况下，则通过富含潜在增加胰岛素抵抗和炎症的高级糖基化终产物的阿斯巴甜甜味剂和焦糖色素的额外贡献导致脂肪积累。这篇综述强调了一些关于软饮料的事实，回顾了果糖代谢，并解释了果糖如何导致肥胖、糖尿病、代谢综合征和 NAFLD 的发展。
