Capella G L, Altomare G F
Department of Dermatology, Ospedale Maggiore IRCCS, University of Milan, Milan, Italy.
Mycoses. 2003 Feb;46(1-2):67-70. doi: 10.1046/j.1439-0507.2003.00800.x.
We report a case of tinea corporis caused by a cattle-derived strain of Trichophyton mentagrophytes in a 44-year-old male affected by cutaneous T-cell lymphoma (CTCL, so-called mycosis fungoides). Fungal colonization of glabrous skin was strictly confined within pre-existing lymphomatous plaques. Either oral itraconazole or griseofulvin, or topical terbinafine were ineffective until the patient, who was treated with systemic retinoids and interferon-alpha for his CTCL, was shifted from leucocyte to lymphoblastoid interferon. The hypothesis that a local immunodisturbance could be responsible for the selective superimposition of tinea on CTCL lesions ('mycosis on mycosis'), and that such an immunodisturbance could be partially corrected by the interferon switch is discussed.
我们报告了一例由牛源须癣毛癣菌菌株引起的体癣病例，患者为一名44岁患有皮肤T细胞淋巴瘤（CTCL，即所谓蕈样肉芽肿）的男性。光滑皮肤的真菌定植严格局限于先前存在的淋巴瘤斑块内。口服伊曲康唑或灰黄霉素，或外用特比萘芬均无效，直到该患者因CTCL接受全身维甲酸和α干扰素治疗，从白细胞干扰素改为淋巴母细胞样干扰素后才起效。本文讨论了局部免疫紊乱可能是体癣选择性叠加在CTCL病变上（“癣上癣”）的原因，以及这种免疫紊乱可通过干扰素转换得到部分纠正的假说。
