Alteras I, David M, Feuerman E J, Morojonski G
Mycopathologia. 1982 Nov 19;80(2):83-8.
A 71-year-old female with a widespread double mycotic infection caused by C. Albicans and T. rubrum was discovered to be suffering from mycosis fungoides. Clinically she was found to have large, polycyclic erythematous plaques with scaly, slightly infiltrated borders, covering almost all areas of the glabrous skin, and also involving the scalp (with no hair penetration), the soles and palms, toe-webs, finger and toe nails; there was also perleche and oral thrush. Cultures yielded C. albicans from most of the skin lesions, from the scalp, mouth, finger nails and urine and stool specimens, and T. rubrum from intermingled skin specimens, from the palms and soles and toe-nails. Blood culture was negative as were intracutaneous tests with fungal antigens and tuberculin. Histological examination confirmed the fungal invasion of the horny layer and at the same time revealed an underlying pathologic picture of mycosis fungoides, the lesions having been masked by the mycotic eruption. Intensive cytostatic and antifungal therapy led to a transient improvement but shortly thereafter there was a relapse of the fungal and lymphoproliferative manifestations and the patient died in septic shock.
一名71岁女性，患有由白色念珠菌和红色毛癣菌引起的广泛双重真菌感染，被发现患有蕈样肉芽肿。临床上，她有大片多环状红斑斑块，边界有鳞屑、轻度浸润，几乎覆盖了所有无毛皮肤区域，还累及头皮（毛发未穿透）、手掌和脚底、趾间、手指和脚趾甲；此外还有口角炎和口腔念珠菌病。从大多数皮肤病变、头皮、口腔、指甲以及尿液和粪便标本中培养出白色念珠菌，从混合皮肤标本、手掌和脚底以及趾甲中培养出红色毛癣菌。血培养为阴性，真菌抗原和结核菌素皮内试验也为阴性。组织学检查证实角质层有真菌侵袭，同时显示出蕈样肉芽肿的潜在病理图像，病变被真菌疹掩盖。强化的细胞毒性和抗真菌治疗导致短暂改善，但此后不久真菌和淋巴增殖性表现复发，患者死于感染性休克。
