Gerber J D, Marron A E
Am J Vet Res. 1976 Feb;37(2):133-8.
The antibody-mediated immune response (AMIR) of dogs to measles and canine distemper viruses has been described. However, there is little information on the cell-mediated immune response (CMIR). The AMIR and the CMIR of dogs to canine distemper and to measles were examined. The CMIR was determined for 6 weeks by measuring the 3H-thymidine uptake by immune lymphocytes in the lymphocyte transformation test. Concurrently, canine distemper and measles virus serum-neutralization antibodies were measured by a microtitration serum-neutralization test. Dogs vaccinated with canine distemper virus had a CMIR and an AMIR to canine distemper. However, measles virus-vaccinated dogs had only a CMIR to canine distemper. A CMIR in the absence of an AMIR indicates that cell-mediated immunity is the most important immune mechanism in protecting measles virus-vaccinated dogs against canine distemper. Development of CMIR and AMIR to canine distemper and measles antigens depended on the age of the dog at the time of vaccination. Adult and juvenile dogs had immune responses to both canine distemper and measles. Neither virus, however, elicited an immune response in neonates.
犬对麻疹病毒和犬瘟热病毒的抗体介导免疫反应（AMIR）已有描述。然而，关于细胞介导免疫反应（CMIR）的信息却很少。研究了犬对犬瘟热和麻疹的AMIR和CMIR。通过在淋巴细胞转化试验中测量免疫淋巴细胞对³H-胸腺嘧啶核苷的摄取，连续6周测定CMIR。同时，通过微量滴定血清中和试验检测犬瘟热和麻疹病毒血清中和抗体。接种犬瘟热病毒的犬对犬瘟热有CMIR和AMIR。然而，接种麻疹病毒的犬仅对犬瘟热有CMIR。在没有AMIR的情况下出现CMIR表明，细胞介导免疫是保护接种麻疹病毒的犬抵抗犬瘟热的最重要免疫机制。犬对犬瘟热和麻疹抗原的CMIR和AMIR的发育取决于接种时犬的年龄。成年犬和幼年犬对犬瘟热和麻疹均有免疫反应。然而，这两种病毒均未在新生犬中引发免疫反应。
