Matalliotakis Ioannis M, Goumenou Anastasia G, Koumantakis George E, Athanassakis Irene, Dionyssopoulou Eva, Neonaki Maria A, Vassiliadis Simon
University of Crete, Faculty of Medicine-University Hospital and Department of Biology, Heraklion, Crete, Greece.
J Soc Gynecol Investig. 2003 Feb;10(2):118-21. doi: 10.1016/s1071-5576(02)00261-7.
An increased incidence of endometriosis in the first-degree relatives of patients with endometriosis has been reported, suggesting a familial predisposition and possible genetic influence. In this study, we present a family with four members who have histologically proven endometriosis (mother and three daughters) in two generations and one member with suspected endometriosis in the third generation. The aim of this study was to investigate the presence of serum-soluble class I and class II human leukocyte antigen (sHLA) levels, because they have been shown to be reduced in women with endometriosis. We also studied the levels of vascular endothelial growth factor (VEGF) and epidermal growth factor-receptor (EGF-Rc) whose function in angiogenesis implies an active role in endometriosis.
Apart from the family members under study, the control groups consisted of 38 women with endometriosis and 30 without any pelvic disease. All the soluble factors under investigation were measured by an enzyme-linked immunosorbent assay technique using a specific immunoassay.
All the affected family members and the 38 women with endometriosis had very low levels of serum-soluble class I and class II HLA levels compared with healthy subjects. The circulating levels of VEGF were higher in the endometriosis group than the healthy control group, a pattern in accordance with the family members. On the contrary, EGF-Rc was negative in controls and women with endometriosis, with the exception of certain family members in specific stages of endometriosis.
We studied the association of endometriosis with circulating levels of human leukocyte antigens and VEGF in two generations of a single family (mother and three daughters). These markers were expressed distinctly in women with familial endometriosis.
有报道称子宫内膜异位症患者的一级亲属中，子宫内膜异位症的发病率有所增加，这表明存在家族易感性以及可能的遗传影响。在本研究中，我们呈现了一个家族，其中两代有四名成员经组织学证实患有子宫内膜异位症（母亲和三个女儿），第三代有一名成员疑似患有子宫内膜异位症。本研究的目的是调查血清可溶性 I 类和 II 类人白细胞抗原（sHLA）水平，因为已证明子宫内膜异位症女性的这些水平会降低。我们还研究了血管内皮生长因子（VEGF）和表皮生长因子受体（EGF - Rc）的水平，它们在血管生成中的作用意味着在子宫内膜异位症中发挥积极作用。
除了所研究的家庭成员外，对照组由 38 名患有子宫内膜异位症的女性和 30 名无任何盆腔疾病的女性组成。所有研究的可溶性因子均采用特定免疫测定的酶联免疫吸附测定技术进行测量。
与健康受试者相比，所有受影响的家庭成员以及
