Aboudola Samer, Kotloff Karen L, Kyne Lorraine, Warny Michel, Kelly Eoin C, Sougioultzis Stavros, Giannasca Paul J, Monath Thomas P, Kelly Ciarán P
Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Infect Immun. 2003 Mar;71(3):1608-10. doi: 10.1128/IAI.71.3.1608-1610.2003.
There is a strong association between serum antibody responses to toxin A and protection against Clostridium difficile diarrhea. A parenteral C. difficile toxoid vaccine induced very-high-level responses to anti-toxin A immunoglobulin G (IgG) in the sera of healthy volunteers. After vaccination, the concentrations of anti-toxin A IgG in the sera of all 30 recipients exceeded the concentrations that were associated with protection in previous clinical studies. Furthermore, the median concentration of serum anti-toxin A IgG in the test group was 50-fold higher than the previous threshold. These findings support the feasibility of using a vaccine to protect high-risk individuals against C. difficile-associated diarrhea and colitis.
血清对毒素A的抗体反应与预防艰难梭菌腹泻之间存在密切关联。一种肠道外注射的艰难梭菌类毒素疫苗在健康志愿者血清中诱导出了对抗毒素A免疫球蛋白G（IgG）的非常高水平的反应。接种疫苗后，所有30名接受者血清中的抗毒素A IgG浓度均超过了先前临床研究中与保护作用相关的浓度。此外，试验组血清抗毒素A IgG的中位数浓度比先前的阈值高50倍。这些发现支持了使用疫苗保护高危个体免受艰难梭菌相关性腹泻和结肠炎侵害的可行性。
