组蛋白乙酰转移酶的MYST家族。

The MYST family of histone acetyltransferases.

作者信息

Utley R T, Côté J

机构信息

Laval University Cancer Research Center, Hôtel-Dieu de Québec (CHUQ), 11 Côte du Palais, Quebec City, QC G1R 2J6, Canada.

出版信息

Curr Top Microbiol Immunol. 2003;274:203-36. doi: 10.1007/978-3-642-55747-7_8.

DOI:10.1007/978-3-642-55747-7_8

PMID:12596909

Abstract

Multiple chromatin modifying proteins and multisubunit complexes have been characterized in recent years. Histone acetyltransferase (HAT) activities have been the most thoroughly studied, both biochemically and functionally. This review sums up the current knowledge on a specific group of proteins that is extremely well conserved throughout evolution, the MYST family of histone acetyltransferases. These proteins play critical roles in various nuclear functions and the control of cell proliferation.

摘要

近年来，多种染色质修饰蛋白和多亚基复合物已得到表征。从生物化学和功能方面来看，组蛋白乙酰转移酶（HAT）的活性研究得最为透彻。这篇综述总结了关于一组在整个进化过程中极其保守的特定蛋白质——组蛋白乙酰转移酶MYST家族的现有知识。这些蛋白质在各种核功能以及细胞增殖控制中发挥着关键作用。