ESA1是一种组蛋白乙酰转移酶，对酵母生长至关重要。
ESA1 is a histone acetyltransferase that is essential for growth in yeast.
作者信息
Smith E R, Eisen A, Gu W, Sattah M, Pannuti A, Zhou J, Cook R G, Lucchesi J C, Allis C D
机构信息
Department of Biology, University of Rochester, Rochester, NY 14627, USA.
出版信息
Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3561-5. doi: 10.1073/pnas.95.7.3561.
Abstract
Posttranslational acetylation of core histone amino termini has long been associated with transcriptionally active chromatin. Recent reports have demonstrated histone acetyltransferase activity in a small group of conserved transcriptional regulators directly linked to gene activation. In addition, the presence of a putative acetyltransferase domain has been discovered in a group of proteins known as the MYST family (for its founding members MOZ, YBF2/SAS3, SAS2, and Tip60). Members of this family are implicated in acute myeloid leukemia (MOZ), transcriptional silencing in yeast (SAS2 and YBF2/SAS3), HIV Tat interaction in humans (Tip60), and dosage compensation in Drosophila (MOF). In this report, we express a yeast ORF with homology to MYST family members and show it possesses histone acetyltransferase activity. Unlike the other MYST family members in Saccharomyces cerevisiae this gene is essential for growth.
摘要
核心组蛋白氨基末端的翻译后乙酰化长期以来一直与转录活性染色质相关。最近的报告表明，一小部分保守的转录调节因子具有组蛋白乙酰转移酶活性，这些调节因子与基因激活直接相关。此外，在一组被称为MYST家族的蛋白质中发现了一个假定的乙酰转移酶结构域（因其创始成员MOZ、YBF2/SAS3、SAS2和Tip60而得名）。该家族成员与急性髓性白血病（MOZ）、酵母中的转录沉默（SAS2和YBF2/SAS3）、人类中的HIV Tat相互作用（Tip60）以及果蝇中的剂量补偿（MOF）有关。在本报告中，我们表达了一个与MYST家族成员具有同源性的酵母开放阅读框，并表明它具有组蛋白乙酰转移酶活性。与酿酒酵母中的其他MYST家族成员不同，该基因对生长至关重要。
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本文引用的文献
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ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS.组蛋白的乙酰化和甲基化及其在RNA合成调控中的可能作用。
Proc Natl Acad Sci U S A. 1964 May;51(5):786-94. doi: 10.1073/pnas.51.5.786.
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Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo.酵母Gcn5p的组蛋白乙酰转移酶活性在体内对靶基因的激活是必需的。
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Novel substrate specificity of the histone acetyltransferase activity of HIV-1-Tat interactive protein Tip60.HIV-1-Tat相互作用蛋白Tip60的组蛋白乙酰转移酶活性的新型底物特异性
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7
mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila.mof是一种推定的乙酰转移酶基因，与人类的Tip60和MOZ基因以及酵母的SAS基因相关，在果蝇的剂量补偿中是必需的。
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8
The role of Sas2, an acetyltransferase homologue of Saccharomyces cerevisiae, in silencing and ORC function.酿酒酵母乙酰转移酶同源物Sas2在基因沉默和复制起始点识别复合物功能中的作用。
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Histone acetyltransferases in control.处于控制状态的组蛋白乙酰转移酶。
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