阿司匹林对类风湿关节炎（RA）或系统性红斑狼疮（SLE）患者及正常志愿者肝脏检查结果的影响。

Effect of aspirin on liver tests in patients with RA or SLE and in normal volunteers.

作者信息

Seaman W E, Plotz P H

出版信息

Arthritis Rheum. 1976 Mar-Apr;19(2):155-60. doi: 10.1002/art.1780190205.

DOI:10.1002/art.1780190205

Abstract

Aspirin was given to 20 patients with RA, 16 patients with SLE, and 3 normal volunteers. Four of the RA patients, 7 of the SLE patients, and 1 normal volunteer developed abnormal liver tests, during the study. The abnormalities (elevated transaminases) were most frequent and of rapid onset in patients with cliniclaly active SLE. Increases in BUN and creatinine related to aspirin were observed in several subjects. In a retrospective survey of 80 patients with SLE, aspirin appeared responsible for two-thirds of episodes of liver test abnormalities in 19 patients.

摘要

对20例类风湿性关节炎（RA）患者、16例系统性红斑狼疮（SLE）患者和3名正常志愿者给予阿司匹林治疗。在研究期间，20例RA患者中有4例、16例SLE患者中有7例以及1名正常志愿者出现肝功能检查异常。肝功能异常（转氨酶升高）在临床活动期SLE患者中最为常见且起病迅速。在几名受试者中观察到与阿司匹林相关的血尿素氮（BUN）和肌酐升高。在一项对80例SLE患者的回顾性调查中，阿司匹林似乎是导致19例患者中三分之二肝功能检查异常发作的原因。