Kohno S, Kaku M, Tsutsui K, Motokawa M, Ohtani J, Tenjo K, Tohma Y, Tokimasa C, Fujita T, Kawata T, Tanne K
Department of Orthodontics, Hiroshima University Faculty of Dentistry, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
J Dent Res. 2003 Mar;82(3):177-82. doi: 10.1177/154405910308200306.
Vascular endothelial growth factor (VEGF) has an ability to induce functional osteoclasts as well as neovascularization. We recently reported that the number of osteoclasts was enhanced by the injection of recombinant human VEGF (rhVEGF) with the application of mechanical force for experimental tooth movement. In this study, the expression of VEGF was detected in osteoblasts on the tension side of the alveolar bone. Moreover, the rate of tooth movement was significantly increased in the rhVEGF injection groups compared with the controls. These results suggested that VEGF, highly expressed by mechanical stimuli, enhances the number of osteoclasts as a paracrine factor, and that the amount of tooth movement is accelerated by both endogenous VEGF and injected rhVEGF.
血管内皮生长因子（VEGF）具有诱导功能性破骨细胞以及新血管形成的能力。我们最近报道，在施加机械力以进行实验性牙齿移动时，注射重组人VEGF（rhVEGF）可增加破骨细胞数量。在本研究中，在牙槽骨张力侧的成骨细胞中检测到了VEGF的表达。此外，与对照组相比，rhVEGF注射组的牙齿移动速率显著增加。这些结果表明，由机械刺激高度表达的VEGF作为旁分泌因子增加破骨细胞数量，并且内源性VEGF和注射的rhVEGF均加速牙齿移动量。
